BCL2L1 and MTOR

Number of citations of the paper that reports this interaction (PubMedID 20080789)
140

Data Source:
BioGRID (enzymatic study)

		BCL2L1	MTOR
Description		BCL2 like 1	mechanistic target of rapamycin kinase
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Centrosome Cytosol Integral Component Of Membrane Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane PML Body Dendrite TORC1 Complex TORC2 Complex Neuronal Cell Body Phagocytic Vesicle Glutamatergic Synapse Postsynaptic Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding TFIIIC-class Transcription Factor Complex Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Ribosome Binding Translation Regulator Activity Phosphoprotein Binding Protein Serine Kinase Activity
	Biological Process	Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Germ Cell Development Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Suppression By Virus Of Host Apoptotic Process Regulation Of Cytokinesis Response To Cytokine Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Neuron Apoptotic Process Defense Response To Virus Regulation Of Mitochondrial Membrane Potential Mitochondrion Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Cell Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Regulation Of Cell Growth Negative Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation T-helper 1 Cell Lineage Commitment Heart Morphogenesis Heart Valve Morphogenesis Regulation Of Glycogen Biosynthetic Process Energy Reserve Metabolic Process 'de Novo' Pyrimidine Nucleobase Biosynthetic Process Protein Phosphorylation Lysosome Organization Germ Cell Development Brain Development Cell Aging Response To Nutrient Long-term Memory Regulation Of Cell Size Visual Learning Cellular Response To Starvation Post-embryonic Development Negative Regulation Of Autophagy Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Myotube Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Negative Regulation Of Muscle Atrophy Response To Activity Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Spinal Cord Development Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Ruffle Organization Regulation Of Myelination Response To Nutrient Levels Cellular Response To Nutrient Levels TOR Signaling Regulation Of Fatty Acid Beta-oxidation Regulation Of Response To Food Activation Of Protein Kinase B Activity Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Insulin Regulation Of Actin Cytoskeleton Organization Cellular Response To Amino Acid Starvation Social Behavior Multicellular Organism Growth TORC1 Signaling Wound Healing Response To Cocaine Regulation Of Circadian Rhythm Regulation Of GTPase Activity Response To Amino Acid Anoikis Response To Morphine Regulation Of Carbohydrate Utilization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Osteoclast Differentiation Positive Regulation Of Translation Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase III Protein Autophosphorylation Positive Regulation Of Lipid Biosynthetic Process MRNA Stabilization Rhythmic Process Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Voluntary Musculoskeletal Movement Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Keratinocyte Migration Nucleus Localization Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Cardiac Muscle Contraction Maternal Process Involved In Female Pregnancy Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Dendritic Spine Development Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Amino Acid Stimulus Cellular Response To Leucine Cellular Response To Hypoxia Regulation Of Brown Fat Cell Differentiation Regulation Of Membrane Permeability Regulation Of Translation At Synapse, Modulating Synaptic Transmission Regulation Of Cellular Response To Heat Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Eating Behavior Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Negative Regulation Of Cholangiocyte Apoptotic Process Positive Regulation Of Granulosa Cell Proliferation Positive Regulation Of Skeletal Muscle Hypertrophy Negative Regulation Of Iodide Transmembrane Transport Positive Regulation Of Cytoplasmic Translational Initiation Cellular Response To Leucine Starvation
Pathways		BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome RAS processing STAT5 activation downstream of FLT3 ITD mutants	PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Isosorbide Gossypol	Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prudent dietary pattern ( 28644415) Putamen volume ( 29147026) Subcortical brain region volumes ( 25607358)	Beard thickness ( 26926045) Body mass index ( 25673413) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body shape index ( 34021172) Corneal curvature ( 24963161) Heel bone mineral density ( 28869591) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		111 interacting genes: ACTB AKT1 ANTXR1 APAF1 AURKA AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIP5 BNIPL C10orf67 CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CHEK1 CREB3 CRYAA CRYAB CYCS DOCK7 EDRF1 ELOVL4 ERGIC3 FBP1 FKBP8 G0S2 GLOD4 GNLY GOLM1 GORAB GSK3A GSK3B HNRNPA1 HRK IKZF3 IRS1 IRS2 LARP1 MAPK14 MAPK8 MAPK9 MAPKAPK2 MCL1 METTL23 MOAP1 MTIF3 MTNR1B MTOR NLRP1 PARK7 PDIA4 PINK1 PLD3 PLK1 PLK3 PMAIP1 PPHLN1 PPP1CA PRKN PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 REEP4 RHBDD2 RIC3 RNF183 RNF4 RTN1 RTN4 RYR3 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TMEM50B TP53 TP53BP2 TPT1 UBE2I UBR1 UHRF2 VAC14 VDAC1 ZFYVE1 ZHX1 ZNF219	59 interacting genes: AKT1 AKT1S1 AMBRA1 BCL2L1 C7orf25 CA6 CDC37 CFP CLIP1 DCP2 EIF3F EIF4EBP1 EIF4EBP2 EP300 ESR1 FBXO8 FKBP1A FKBP8 GPHN GSK3B HRAS IRS1 MAF1 MECR MLST8 NPPB NRAS PA2G4 PDPK1 PIK3CD PLD2 PPP2R2A PREX1 PRKAA1 PRKCA PRR5L RHEB RHEBL1 RICTOR RPS6KA1 RPS6KB1 RPS6KB2 RPTOR RRAGB SEPTIN2 SKP2 SLC2A5 SLC45A1 SLC9A1 STAT3 SUMO1 TELO2 TERT TRAF6 UBQLN1 UVRAG WIPI2 YWHAQ ZNRF2
Entrez ID		598	2475
HPRD ID		02497	03134
Ensembl ID		ENSG00000171552	ENSG00000198793
Uniprot IDs		A0A0S2Z3C5 Q07817 Q5TE63	P42345
PDB IDs		1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2ME8 2ME9 2MEJ 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3WIZ 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4BPK 4C52 4C5D 4CIN 4EHR 4HNJ 4IEH 4PPI 4QVE 4QVF 4QVX 4TUH 4Z9V 5AGW 5AGX 5B1Z 5C3G 5FMJ 5FMK 5VAY 5VX3 6BF2 6DCN 6DCO 6F46 6HJL 6IJQ 6O0K 6O0L 6O0M 6O0O 6O0P 6RNU 6ST2 6VWC 6X7I 6ZHC 7CA4 7JGV 7JGW	1AUE 1FAP 1NSG 2FAP 2GAQ 2NPU 2RSE 3FAP 3JBZ 4DRH 4DRI 4DRJ 4FAP 4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5GPG 5H64 5WBH 5WBU 5WBY 5ZCS 6BCU 6BCX 6M4U 6M4W 6SB0 6SB2 6ZWM 6ZWO
Enriched GO Terms of Interacting Partners?
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