BCL2L2 and TMX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BCL2L2	TMX1
Description		BCL2 like 2	thioredoxin related transmembrane protein 1
Image
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Cytosol Bcl-2 Family Protein Complex	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity BH Domain Binding Disordered Domain Specific Binding	Protein Binding Disulfide Oxidoreductase Activity
	Biological Process	Response To Ischemia Spermatogenesis Brain Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Apoptotic Process Sertoli Cell Proliferation Cellular Response To Estradiol Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Amyloid-beta Cellular Response To Glycine Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Endoplasmic Reticulum Stress
Pathways
Drugs		Navitoclax
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172)	Cancer ( 29299148) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576)
Interacting Genes		53 interacting genes: ANKS6 APOC1 APOC2 APOC4 ATP5PF BAD BAK1 BAX BBC3 BCL2L11 BHLHA9 BID BIK BMF BNIP3 BNIP5 C10orf67 CD79A CHODL CIDEB CISD2 CLDN7 ERVFRD-1 FATE1 G0S2 GORAB GPR151 GPX8 HRK KASH5 KCNJ6 LMNA LRRIQ1 MGST2 MUC1 PANX1 PPP1CA PSCA RHBDD2 S100B SAR1A SGPL1 SLC35C2 SLC35E3 SLC39A2 SLC39A6 STOM SUSD3 TCF4 TEX11 TMEM139 TMX1 TP53	13 interacting genes: BCL2L2 CCR1 CDC42 DNAAF2 FAS FKBP8 GET3 GIMAP1 GIMAP5 LHFPL5 PMP22 SPI1 SULT2A1
Entrez ID		599	81542
HPRD ID		03569	15590
Ensembl ID		ENSG00000129473	ENSG00000139921
Uniprot IDs		Q92843	Q9H3N1
PDB IDs		1MK3 1O0L 1ZY3 2Y6W 4CIM	1X5E
Enriched GO Terms of Interacting Partners?
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