RFC5 and CHTF18

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, pull down)

		RFC5	CHTF18
Description		replication factor C subunit 5	chromosome transmission fidelity factor 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DNA Replication Factor C Complex Ctf18 RFC-like Complex	Nucleus Nucleoplasm Cytosol Membrane Ctf18 RFC-like Complex
	Molecular Function	DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA Helicase Activity Enzyme Binding	DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding Single-stranded DNA Helicase Activity
	Biological Process	DNA Replication DNA-dependent DNA Replication DNA Repair DNA Duplex Unwinding Positive Regulation Of DNA-directed DNA Polymerase Activity	DNA Replication Cell Cycle DNA Duplex Unwinding Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint	Polymerase switching on the C-strand of the telomere
Drugs
Diseases
GWAS		Chronic rhinosinusitis ( 33393196) Metabolite levels ( 23823483) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Physiological traits ( 31902109)	Body mass index ( 26426971) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		36 interacting genes: ARID5A BIRC2 CCNC CHTF18 COPS6 DAPK1 DDIT4L DYNLL1 EEF1A1 EML2 EXOSC8 FAM166B KRT34 LMO3 LRIF1 MED31 N4BP3 NAB2 NR5A1 PCNA PPP1R16B PTEN RBM48 RFC2 RFC4 SUMO2 TASOR2 TRIM38 TSNAX UNC119 XAF1 XIAP YPEL3 ZMAT1 ZNF19 ZNF426	5 interacting genes: CRK PCNA RFC4 RFC5 STAT3
Entrez ID		5985	63922
HPRD ID		02677	13059
Ensembl ID		ENSG00000111445	ENSG00000127586
Uniprot IDs		P40937 Q59GW7	Q8WVB6
PDB IDs		1LFS 6VVO
Enriched GO Terms of Interacting Partners?
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