KLHL12 and CCBE1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		KLHL12	CCBE1
Description		kelch like family member 12	collagen and calcium binding EGF domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Collagen Trimer Extracellular Space Extracellular Matrix
	Molecular Function	Protein Binding Identical Protein Binding	Protease Binding Calcium Ion Binding Protein Binding Collagen Binding
	Biological Process	Protein Monoubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating	Lymphangiogenesis Sprouting Angiogenesis Respiratory System Process Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Processing Lung Development Positive Regulation Of Angiogenesis Venous Blood Vessel Morphogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Lymphangiogenesis
Pathways		Degradation of DVL
Drugs
Diseases
GWAS			Age-related hearing impairment ( 24939585) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Major depressive disorder ( 23857890) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Pre-treatment viral load in HIV-1 infection ( 31219150) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia x sex interaction ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189)
Interacting Genes		62 interacting genes: ARAF ARRDC1 ATXN1 BAG6 BCL6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL2 DVL3 FAM90A1 FBXL17 FGD2 FLNA GLYCTK INMT KEAP1 KHSRP KLHL2 KLHL24 KLHL3 LNPK LNX1 MAPRE1 MED25 MED28 MPP1 MRPL10 MTNR1A MYO15B NDC80 NTAQ1 PDGFRB PEA15 PEF1 PLEKHA4 PNKP PRR13 RGL3 RIN1 RIT1 RNF4 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TCEANC TTBK2 UBE2I VEGFB VTA1 ZBP1 ZBTB4	12 interacting genes: CEP55 COPS6 FBXO7 FXR1 INCA1 KLHL12 KRT27 KRT36 LNX1 SIAH2 STX11 TOX4
Entrez ID		59349	147372
HPRD ID		13925	08703
Ensembl ID		ENSG00000117153	ENSG00000183287
Uniprot IDs		Q53G59 Q9H7R2	Q6UXH8
PDB IDs		2VPJ 6TTK 6V7O
Enriched GO Terms of Interacting Partners?
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