RANGAP1 and MAP3K8

		RANGAP1	MAP3K8
Description		Ran GTPase activating protein 1	mitogen-activated protein kinase kinase kinase 8
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GO Annotations	Cellular Component	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Aggresome Dendrite Nuclear Membrane Intracellular Membrane-bounded Organelle Nuclear Pore Cytoplasmic Filaments Perinuclear Region Of Cytoplasm Mitotic Spindle Axon Cytoplasm Cytoplasmic Periphery Of The Nuclear Pore Complex	Cytosol
	Molecular Function	RNA Binding GTPase Activator Activity Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Signal Transduction Negative Regulation Of Protein Export From Nucleus Response To Axon Injury Activation Of GTPase Activity Cellular Response To Vasopressin	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Bitter beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Lamb consumption ( 32066663) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		23 interacting genes: AXIN2 CCL5 CSNK2A1 DLC1 GNAI1 GNAI3 IPO8 MAP3K8 MUL1 OGT PDGFRL PRKACA PTEN RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2E3 UBE2I USPL1	26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		5905	1326
HPRD ID		03839	01863
Ensembl ID		ENSG00000100401	ENSG00000107968
Uniprot IDs		A0A024R1U0 P46060 Q9BSK3	P41279 Q6FG25
PDB IDs		1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP 5D2M	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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