MAP3K8 and MAP2K4

Number of citations of the paper that reports this interaction (PubMedID 8631303)
86

Data Source:
HPRD (in vitro)

		MAP3K8	MAP2K4
Description		mitogen-activated protein kinase kinase kinase 8	mitogen-activated protein kinase kinase 4
Image
GO Annotations	Cellular Component	Cytosol	Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	Protein Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Signal Transduction JNK Cascade Response To Wounding Peptidyl-tyrosine Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Cellular Senescence Negative Regulation Of Motor Neuron Apoptotic Process
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	44 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK7 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC
Entrez ID		1326	6416
HPRD ID		01863	03213
Ensembl ID		ENSG00000107968	ENSG00000065559
Uniprot IDs		P41279 Q6FG25	P45985
PDB IDs		4Y83 4Y85 5IU2	3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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