CACTIN and CLK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CACTIN	CLK2
Description		cactin, spliceosome C complex subunit	CDC like kinase 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nuclear Body Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Phosphorylation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Protein Phosphorylation Response To Ionizing Radiation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Negative Regulation Of Gluconeogenesis Protein Autophosphorylation
Pathways
Drugs			Fostamatinib
Diseases
GWAS			Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: CLK2 HMGB2 NELFE TRIM39	53 interacting genes: AKT1 ASPSCR1 CACTIN CLASRP CLK1 CLK3 CPSF7 DDIT4L ECE1 EHHADH GMCL1 GTPBP2 KLHL2 LNX1 LUZP4 MRPL4 NXF1 PRM1 PRPF38A PTPN1 RBM39 RNF8 RNPS1 RSRP1 SDCBP SNIP1 SNRNP70 SRPK2 SRRM1 SRSF3 TACC2 TRIM27 TRIM50 U2AF1 UBE2I UBL5 YTHDC1 YWHAG ZNF136 ZNF263 ZNF317 ZNF394 ZNF398 ZNF436 ZNF440 ZNF473 ZNF491 ZNF558 ZNF764 ZNF768 ZNF837 ZRSR2 ZSCAN21
Entrez ID		58509	1196
HPRD ID		18930	04289
Ensembl ID		ENSG00000105298	ENSG00000176444
Uniprot IDs		Q8WUQ7	A8K7I0 B7Z8N6 P49760
PDB IDs		6QDV	3NR9 5UNP 6FYI 6FYK 6FYL 6KHE
Enriched GO Terms of Interacting Partners?
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