SFMBT2 and PHC1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SFMBT2	PHC1
Description		Scm like with four mbt domains 2	polyhomeotic homolog 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Aggresome Nuclear Body Nuclear Speck Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding
	Biological Process	Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated	Histone Ubiquitination Negative Regulation Of Transcription, DNA-templated
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 31036433) Fasting blood insulin (BMI interaction) ( 22581228) Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Monoclonal gammopathy of undetermined significance ( 30737484)	Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: CLK1 L3MBTL3 LYPLA1 PHC1 SCMH1 SCML1 SCML2 SIAH1 SLF2 TFAP4 UBE2O	23 interacting genes: BMI1 FAM9A GMNN HSPA8 PCGF3 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7
Entrez ID		57713	1911
HPRD ID		18853	16009
Ensembl ID		ENSG00000198879	ENSG00000111752
Uniprot IDs		Q5VUG0	P78364 Q6GMQ3 Q6N083
PDB IDs		1WJR	2L8E
Enriched GO Terms of Interacting Partners?
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