PHC1 and SCMH1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		PHC1	SCMH1
Description		polyhomeotic homolog 1	Scm polycomb group protein homolog 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Chromocenter
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding	Chromatin Binding Protein Binding Histone Binding
	Biological Process	Histone Ubiquitination Negative Regulation Of Transcription, DNA-templated	Chromatin Remodeling Spermatogenesis Anterior/posterior Pattern Specification Gene Silencing Negative Regulation Of Transcription, DNA-templated
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs			Mercaptoethanol
Diseases
GWAS		Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737 29892015) General risk tolerance (MTAG) ( 30643258) Height ( 20881960 25282103 23563607 18391952) Hip circumference adjusted for BMI ( 34021172) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928)
Interacting Genes		23 interacting genes: BMI1 FAM9A GMNN HSPA8 PCGF3 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7	22 interacting genes: EWSR1 FXR1 FXR2 GMNN HK1 HPCAL4 LYPLA2 LZTR1 MAGEA12 MAML3 MOB4 PCBD1 PHC1 PHC2 POLR2M SFMBT1 SFMBT2 TMEM11 TOB1 TSC1 UBQLN1 UBQLN4
Entrez ID		1911	22955
HPRD ID		16009	11540
Ensembl ID		ENSG00000111752	ENSG00000010803
Uniprot IDs		P78364 Q6GMQ3 Q6N083	B3KMZ7 Q96GD3
PDB IDs		2L8E	2P0K
Enriched GO Terms of Interacting Partners?
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