LRRC4C and DRAM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LRRC4C	DRAM1
Description		leucine rich repeat containing 4C	DNA damage regulated autophagy modulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Cytoplasm Lysosome Lysosomal Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Cell Adhesion Molecule Binding Cell-cell Adhesion Mediator Activity	Protein Binding
	Biological Process	Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Synaptic Membrane Adhesion	Autophagy Apoptotic Process Regulation Of Autophagy
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cerebellum cortex volume ( 31530798) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cerebrospinal fluid p-tau levels ( 29274321) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) General risk tolerance (MTAG) ( 30643258) High myopia ( 31816047) Iris color (L* coordinate) ( 30895295) Mastocytosis (KIT D816V positive) ( 33421400) Mosquito bite size ( 28199695) Myopia ( 27182965) Osteoporosis-related phenotypes ( 20548944) Pediatric central nervous system tumors (early onset)(pleiotropy) ( 33226468) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Survival in colorectal cancer ( 26586795) Temperament (bipolar disorder) ( 22365631)	Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 30823506) Shigella-associated diarrhea ( 33649051) Systemic lupus erythematosus ( 23273568 33272962)
Interacting Genes		29 interacting genes: AGTRAP BDKRB1 BMP10 BRICD5 CLDN19 CLEC1A CLEC4G CMTM5 CREB3L4 DOLK DRAM1 EMP3 GJB2 LEPROTL1 LHFPL5 MIP NTNG1 PGAP2 PLP2 SERTM1 SMIM1 SNAP47 STX5 TRAF6 TWSG1 VEZT VSTM1 WHRN YIPF6	10 interacting genes: APP C1orf21 CD164L2 CLRN1 CREB3 EVI2B GPR42 LRRC4C MS4A7 TIMMDC1
Entrez ID		57689	55332
HPRD ID		12303	07743
Ensembl ID		ENSG00000148948	ENSG00000136048
Uniprot IDs		Q4JIV9 Q4JIW0 Q9HCJ2	A0A024RBF9 Q8N682
PDB IDs		3ZYJ
Enriched GO Terms of Interacting Partners?
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