JCAD and MAP3K8

		JCAD	MAP3K8
Description		junctional cadherin 5 associated	mitogen-activated protein kinase kinase kinase 8
Image		No pdb structure
GO Annotations	Cellular Component	Adherens Junction Ruffle Membrane Perinuclear Region Of Cytoplasm	Cytosol
	Molecular Function		Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation
Pathways			CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Coronary artery disease ( 30104761 33020668) Intraocular pressure ( 29617998) Myocardial infarction ( 33532862)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: IL2RA MAP3K8	26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		57608	1326
HPRD ID		13864	01863
Ensembl ID		ENSG00000165757	ENSG00000107968
Uniprot IDs		Q9P266	P41279 Q6FG25
PDB IDs			4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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