RHOJ and DOCK10

Number of citations of the paper that reports this interaction (PubMedID 15710388)
22

Data Source:
HPRD (in vitro)

		RHOJ	DOCK10
Description		ras homolog family member J	dedicator of cytokinesis 10
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Dendritic Spine Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Molecular_function Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Angiogenesis Endocytosis Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Cdc42 Protein Signal Transduction Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis	B Cell Homeostasis Marginal Zone B Cell Differentiation Small GTPase Mediated Signal Transduction Regulation Of Cell Migration Positive Regulation Of GTPase Activity Dendritic Spine Morphogenesis
Pathways		RHOJ GTPase cycle	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)	Granulocyte percentage of myeloid white cells ( 27863252) IgE levels in asthmatics (D.p. specific) ( 23967269) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Response to bupropion and depression ( 27622933) Response to exercise (triglyceride level interaction) ( 26491034) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		25 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 CDC42EP1 DOCK10 DOCK8 GOLGA2 MEOX2 PAK1 PAK2 PAK3 PAK5 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS WASL ZNF426	4 interacting genes: CCDC102B LURAP1 MAGEA11 RHOJ
Entrez ID		57381	55619
HPRD ID		09632	10919
Ensembl ID		ENSG00000126785	ENSG00000135905
Uniprot IDs		A0A024R692 Q7Z513 Q9H4E5	Q96BY6
PDB IDs			6TKY 6TKZ 6TM1
Enriched GO Terms of Interacting Partners?
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