RHOJ and PAK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RHOJ	PAK3
Description		ras homolog family member J	p21 (RAC1) activated kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Extracellular Exosome	Cytoplasm Endosome Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Angiogenesis Endocytosis Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Cdc42 Protein Signal Transduction Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Axonogenesis Positive Regulation Of Fibroblast Migration Dendrite Development Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Organic Cyclic Compound Positive Regulation Of DNA Biosynthetic Process
Pathways		RHOJ GTPase cycle	Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)
Interacting Genes		25 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 CDC42EP1 DOCK10 DOCK8 GOLGA2 MEOX2 PAK1 PAK2 PAK3 PAK5 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS WASL ZNF426	13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1
Entrez ID		57381	5063
HPRD ID		09632	02142
Ensembl ID		ENSG00000126785	ENSG00000077264
Uniprot IDs		A0A024R692 Q7Z513 Q9H4E5	B2RCU6 O75914
PDB IDs			6FD3
Enriched GO Terms of Interacting Partners?
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