SMURF1 and OXSR1

Number of citations of the paper that reports this interaction (PubMedID 15761153)
269

Data Source:
HPRD (in vivo)

		SMURF1	OXSR1
Description		SMAD specific E3 ubiquitin protein ligase 1	oxidative stress responsive kinase 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Exosome	Cytosol Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Phospholipid Binding Activin Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Export From Nucleus Ectoderm Development Protein Ubiquitination Cell Differentiation BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Receptor Catabolic Process Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Engulfment Of Target By Autophagosome Substrate Localization To Autophagosome Protein Targeting To Vacuole Involved In Autophagy Protein Localization To Plasma Membrane Positive Regulation Of Dendrite Extension Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Protein Phosphorylation Response To Oxidative Stress Signal Transduction Osmosensory Signaling Pathway Positive Regulation Of T Cell Chemotaxis Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Chemokine
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Fostamatinib
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 28067908 23128233) Lack of premeditation ( 30718321) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Ulcerative colitis ( 28067908 20228798)	Gut microbiota (bacterial taxa) ( 27723756) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		191 interacting genes: ADRM1 ANAPC5 ANKRD13A ANKRD13D ANKRD50 ANKS4B ANXA6 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASCC2 ASH2L ATXN3 AVEN AXIN1 BMPR2 BTK BTRC C9orf78 CALCOCO1 CCDC69 CCM2 CDC40 CDK14 CDKL1 CSNK1D CSNK2A2 CTNNB1 CTNND1 CTTN CUEDC1 CUL5 CXXC1 DDX54 DNAJC7 DUSP13 DVL2 ECSIT ELOF1 ELP3 ENTR1 EPHA1 EPN1 ETV6 FAF2 FBXL15 FBXO3 FBXO30 FCHO1 FES FGF12 FGR FKBP3 FSCN1 FZR1 GNG11 GRIPAP1 GRK3 HDGFL3 HIP1 HOMER2 ILRUN IMPACT ING2 INPP5B IRAK2 ITGB1BP1 ITK JUNB KRT36 LATS1 LCK LHX9 LIMS1 LMNA LONRF3 MAP3K10 MAP3K2 MAP3K3 MAP3K9 MAP4K5 MARK2 MATK MEPCE MINDY3 MSN NAA16 NDFIP2 NEDD8 NEK2 NSD2 ODF2 OTUD6B OXSR1 PADI4 PAK1 PAK1IP1 PDGFRA PDLIM7 PICALM PIP5K1C PLEKHO1 POLR2A PRKCA PRKCG PRKCI PRR16 PSMD4 PSME3 PTEN PWP1 RABEP1 RAD23A RASD2 RBCK1 RHOA RHOB RHPN2 RIOK3 RIPK2 RIT1 RNF11 RNF114 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SCYL1 SENP8 SF3A1 SLAIN2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SPART SQSTM1 SRSF4 SRSF5 STK31 STK35 STRAP STUB1 TAB1 TAOK3 TBK1 TLN1 TNIK TNIP2 TNK2 TNNT1 TOM1 TOM1L2 TPM4 TRAF4 TRIP10 TTC17 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2K UBE2L3 UBE2M UBE2V1 UBQLN1 UBQLN2 UBTF UBXN1 UBXN6 UBXN7 USP45 USP9X WDR61 WEE1 WFS1 XPO1 ZFAND5	13 interacting genes: APP BMPR1B GORASP1 OGT PAK1 RELL1 RELL2 SLC12A1 SLC12A2 SLC12A6 SMURF1 STT3B TGFBR1
Entrez ID		57154	9943
HPRD ID		06902	06809
Ensembl ID		ENSG00000198742	ENSG00000172939
Uniprot IDs		Q9HCE7	O95747
PDB IDs		2LAZ 2LB0 2LB1 2LTX 3PYC	2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?
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