SMURF1 and WFS1

Number of citations of the paper that reports this interaction (PubMedID 21454619)
24

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SMURF1	WFS1
Description		SMAD specific E3 ubiquitin protein ligase 1	wolframin ER transmembrane glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Secretory Granule Integral Component Of Endoplasmic Reticulum Membrane Integral Component Of Synaptic Vesicle Membrane Dendrite
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Phospholipid Binding Activin Binding Ubiquitin Protein Ligase Activity I-SMAD Binding R-SMAD Binding	Protein Binding Calmodulin Binding Ubiquitin Protein Ligase Binding Calcium-dependent Protein Binding ATPase Binding Proteasome Binding DNA-binding Transcription Factor Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Export From Nucleus Ectoderm Development Protein Ubiquitination Cell Differentiation BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Receptor Catabolic Process Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Engulfment Of Target By Autophagosome Substrate Localization To Autophagosome Protein Targeting To Vacuole Involved In Autophagy Protein Localization To Plasma Membrane Positive Regulation Of Dendrite Extension Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Pancreas Development Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Olfactory Behavior Glucose Homeostasis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Asymmetric localization of PCP proteins Hedgehog 'on' state Hedgehog 'on' state Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620) Inflammatory bowel disease ( 28067908 23128233) Lack of premeditation ( 30718321) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Ulcerative colitis ( 28067908 20228798)	Cisplatin-induced ototoxicity ( 28039263) High density lipoprotein cholesterol levels ( 32902719) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 19734900 29632382 31118516 32499647 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		191 interacting genes: ADRM1 ANAPC5 ANKRD13A ANKRD13D ANKRD50 ANKS4B ANXA6 AP2B1 APBB2 APP ARHGAP15 ARHGAP31 ARHGEF9 ARL14 ARL4D ASCC2 ASH2L ATXN3 AVEN AXIN1 BMPR2 BTK BTRC C9orf78 CALCOCO1 CCDC69 CCM2 CDC40 CDK14 CDKL1 CSNK1D CSNK2A2 CTNNB1 CTNND1 CTTN CUEDC1 CUL5 CXXC1 DDX54 DNAJC7 DUSP13 DVL2 ECSIT ELOF1 ELP3 ENTR1 EPHA1 EPN1 ETV6 FAF2 FBXL15 FBXO3 FBXO30 FCHO1 FES FGF12 FGR FKBP3 FSCN1 FZR1 GNG11 GRIPAP1 GRK3 HDGFL3 HIP1 HOMER2 ILRUN IMPACT ING2 INPP5B IRAK2 ITGB1BP1 ITK JUNB KRT36 LATS1 LCK LHX9 LIMS1 LMNA LONRF3 MAP3K10 MAP3K2 MAP3K3 MAP3K9 MAP4K5 MARK2 MATK MEPCE MINDY3 MSN NAA16 NDFIP2 NEDD8 NEK2 NSD2 ODF2 OTUD6B OXSR1 PADI4 PAK1 PAK1IP1 PDGFRA PDLIM7 PICALM PIP5K1C PLEKHO1 POLR2A PRKCA PRKCG PRKCI PRR16 PSMD4 PSME3 PTEN PWP1 RABEP1 RAD23A RASD2 RBCK1 RHOA RHOB RHPN2 RIOK3 RIPK2 RIT1 RNF11 RNF114 RNF141 RPS27A RRP9 RTKN RUNX3 SASH3 SCYL1 SENP8 SF3A1 SLAIN2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SPART SQSTM1 SRSF4 SRSF5 STK31 STK35 STRAP STUB1 TAB1 TAOK3 TBK1 TLN1 TNIK TNIP2 TNK2 TNNT1 TOM1 TOM1L2 TPM4 TRAF4 TRIP10 TTC17 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2G1 UBE2K UBE2L3 UBE2M UBE2V1 UBQLN1 UBQLN2 UBTF UBXN1 UBXN6 UBXN7 USP45 USP9X WDR61 WEE1 WFS1 XPO1 ZFAND5	17 interacting genes: ADRA2C AQP6 CD59 CD79A CSDE1 DRD2 EIF6 F2RL1 FAM184B FAM209A GAK LTB4R2 MAPK6 S100P SMURF1 TERF1 TRARG1
Entrez ID		57154	7466
HPRD ID		06902	05864
Ensembl ID		ENSG00000198742	ENSG00000109501
Uniprot IDs		Q9HCE7	A0A0S2Z4V6 O76024
PDB IDs		2LAZ 2LB0 2LB1 2LTX 3PYC
Enriched GO Terms of Interacting Partners?
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