POLE4 and POLE2

Number of citations of the paper that reports this interaction (PubMedID 10801849)
28

Data Source:
HPRD (in vitro)

		POLE4	POLE2
Description		DNA polymerase epsilon 4, accessory subunit	DNA polymerase epsilon 2, accessory subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex	Nucleoplasm Epsilon DNA Polymerase Complex Nuclear Body Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	DNA Biosynthetic Process	DNA Replication DNA-dependent DNA Replication DNA Repair Error-prone Translesion Synthesis
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs		Cladribine	Cladribine
Diseases
GWAS		Venous thromboembolism ( 33592630)	Trigger finger ( 32740585)
Interacting Genes		11 interacting genes: B4GALT4 EVA1A HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B REG3G SGO1 UBE3A	25 interacting genes: AGFG1 ATOH1 BAIAP2L2 DRD3 EEF1A1 ERG28 EXOSC4 KAT5 MAPRE1 NID2 PARK7 PKM POLE POLE4 PYGL REL SAP18 SAV1 SORBS3 TBX15 TLE1 TRIM27 UBQLN2 ZBED1 ZNF620
Entrez ID		56655	5427
HPRD ID		16238	16007
Ensembl ID		ENSG00000115350	ENSG00000100479
Uniprot IDs		Q9NR33	P56282
PDB IDs			2V6Z 5VBN
Enriched GO Terms of Interacting Partners?
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