POLE4 and NFYB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		POLE4	NFYB
Description		DNA polymerase epsilon 4, accessory subunit	nuclear transcription factor Y subunit beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity DNA-binding Transcription Factor Binding
	Biological Process	DNA Biosynthetic Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs		Cladribine
Diseases
GWAS		Venous thromboembolism ( 33592630)	Toenail selenium levels ( 25343990)
Interacting Genes		11 interacting genes: B4GALT4 EVA1A HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B REG3G SGO1 UBE3A	27 interacting genes: AGTRAP C1QBP CEBPZ CIITA CNTN2 DRAP1 DUSP6 ELF1 EP300 GRB2 MAOB MEOX2 MYC NFYA NFYC POLE4 POU3F2 SMYD3 SP1 TAF11 TAF12 TAF6 TBP TP53 TP73 YBX1 YBX3
Entrez ID		56655	4801
HPRD ID		16238	01794
Ensembl ID		ENSG00000115350	ENSG00000120837
Uniprot IDs		Q9NR33	A0A024RBG7 F8VSL3 P25208
PDB IDs			1N1J 4AWL 4CSR 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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