PSAP and CELSR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PSAP	CELSR1
Description		prosaposin	cadherin EGF LAG seven-pass G-type receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protease Binding Protein Binding Phospholipid Binding Enzyme Activator Activity Protein Homodimerization Activity Scaffold Protein Binding Ganglioside GM1 Binding Ganglioside GM2 Binding Ganglioside GM3 Binding Ganglioside GT1b Binding Ganglioside GP1c Binding	G Protein-coupled Receptor Activity Calcium Ion Binding
	Biological Process	Sphingolipid Metabolic Process Lysosomal Transport Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Lipid Metabolic Process Prostate Gland Growth Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Beta-galactosidase Activity Ganglioside GM1 Transport To Membrane	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Central Nervous System Development Regulation Of Actin Cytoskeleton Organization Establishment Of Planar Polarity Of Embryonic Epithelium Apical Protein Localization Establishment Of Body Hair Planar Orientation Wnt Signaling Pathway, Planar Cell Polarity Pathway Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Protein Localization Involved In Establishment Of Planar Polarity Cell-cell Adhesion
Pathways		Platelet degranulation Glycosphingolipid metabolism Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation
Drugs		Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases
GWAS		Asthma (childhood onset) ( 23829686) Seasonality and depression ( 30217971)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Leftâ€“right brain asymmetry ( 33723403) Urate levels in obese individuals ( 25811787)
Interacting Genes		21 interacting genes: APPBP2 BACE1 BRCA1 CD1B CELSR1 COPS6 CPEB2 CTSD ERBB2 GBA MAFF NLGN3 PEX5 PRAG1 SGCG SMAD2 SMAD9 TOMM70 UBE3A USP4 ZBED1	2 interacting genes: FGF6 PSAP
Entrez ID		5660	9620
HPRD ID		01460	05160
Ensembl ID		ENSG00000197746	ENSG00000075275
Uniprot IDs		A0A024QZQ2 P07602	Q9NYQ6
PDB IDs		1M12 1N69 1SN6 2DOB 2GTG 2QYP 2R0R 2R1Q 2RB3 2Z9A 3BQP 3BQQ 4DDJ 4UEX 4V2O 6SLR
Enriched GO Terms of Interacting Partners?
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