CELSR1 and FGF6

		CELSR1	FGF6
Description		cadherin EGF LAG seven-pass G-type receptor 1	fibroblast growth factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Cytoplasm Sarcolemma
	Molecular Function	G Protein-coupled Receptor Activity Calcium Ion Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Establishment Of Planar Polarity Neuron Migration Neural Tube Closure Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Central Nervous System Development Regulation Of Actin Cytoskeleton Organization Establishment Of Planar Polarity Of Embryonic Epithelium Apical Protein Localization Establishment Of Body Hair Planar Orientation Wnt Signaling Pathway, Planar Cell Polarity Pathway Orthogonal Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Planar Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Morphogenesis Lateral Sprouting Involved In Lung Morphogenesis Protein Localization Involved In Establishment Of Planar Polarity Cell-cell Adhesion	Cartilage Condensation Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Migration Myoblast Differentiation Positive Regulation Of Cell Division
Pathways			PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 FGFR4 ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295) Leftâ€“right brain asymmetry ( 33723403) Urate levels in obese individuals ( 25811787)	Colorectal cancer ( 23263487) Medication use (antimigraine preparations) ( 31015401) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Phosphorus levels ( 29403010 20558539) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		2 interacting genes: FGF6 PSAP	7 interacting genes: CELSR1 FGFR1 FGFR2 FGFR3 FGFR4 KLRC2 NCALD
Entrez ID		9620	2251
HPRD ID		05160	00623
Ensembl ID		ENSG00000075275	ENSG00000111241
Uniprot IDs		Q9NYQ6	P10767
PDB IDs
Enriched GO Terms of Interacting Partners?
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