PRKCQ and IRS1

Number of citations of the paper that reports this interaction (PubMedID 15364919)
104

Data Source:
HPRD (in vitro, in vivo)

		PRKCQ	IRS1
Description		protein kinase C theta	insulin receptor substrate 1
Image
GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane Aggresome Centriolar Satellite	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Insulin Receptor Complex Caveola Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Kinase C Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Protein Binding Signaling Receptor Complex Adaptor Activity SH2 Domain Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Regulation Of Cell Growth Immune System Process Regulation Of Transcription, DNA-templated Membrane Protein Ectodomain Proteolysis Inflammatory Response Axon Guidance Peptidyl-serine Phosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Telomerase Activity Cell Chemotaxis Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of Telomere Capping Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 2 Cell Activation	Signal Transduction Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Glucose Metabolic Process Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Fatty Acid Beta-oxidation Response To Insulin Cellular Response To Insulin Stimulus Glucose Homeostasis Response To Peptide Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Secretion Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fatty Acid
Pathways		Apoptotic cleavage of cellular proteins Effects of PIP2 hydrolysis Downstream TCR signaling Inactivation, recovery and regulation of the phototransduction cascade FCERI mediated NF-kB activation FCERI mediated NF-kB activation Netrin-1 signaling G alpha (z) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RAS processing	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Signaling by ALK Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Activated NTRK3 signals through PI3K Signaling by ALK fusions and activated point mutants Growth hormone receptor signaling
Drugs		Tamoxifen Staurosporine Phosphonothreonine Dexfosfoserine Fostamatinib	[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
Diseases
GWAS		Asthma ( 31959851 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 31036433 30929738) Autoimmune traits (pleiotropy) ( 30572963) Body mass index in asthmatics ( 23517042) Celiac disease ( 22057235 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic pain ( 33685280) Crohn's disease ( 28067908) Factor VII activity ( 30642921) Immune response to smallpox vaccine (IL-6) ( 22542470) Medication use (thyroid preparations) ( 31015401) Rheumatoid arthritis ( 30423114 18794853 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 19430480 18978792)	Adiponectin levels ( 22479202 31178129) Adiposity ( 21706003) Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823 28724990) Aspartate aminotransferase levels ( 33547301 34315874) Birth weight ( 31043758) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage ( 26833246 28270201) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Circulating leptin levels or type 2 diabetes ( 32341051) Fasting blood insulin ( 25631608 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 33402679 34059833) Glucose homeostasis traits ( 25524916) HDL cholesterol ( 24097068 25961943 20686565) HDL cholesterol levels ( 32203549 28334899) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Insulin levels in response to oral glucose tolerance test (fasting) ( 29093273) Lean body mass ( 28724990) Leg fat mass (lean adjusted) ( 32719433) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Metabolite levels ( 23823483) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Myocardial infarction ( 33532862) Problematic alcohol use ( 32451486) Sexual dimorphism in anthropometric traits ( 23754948) Spleen volume ( 34128465) Triglyceride levels ( 32203549 28334899) Triglycerides ( 24097068 25961943 20686565) Type 2 diabetes ( 22885922 24509480 29358691 30297969 19734900 31118516 20581827) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist circumference ( 25673412) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		28 interacting genes: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GATA3 GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ	81 interacting genes: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK3 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NRDC NTRK1 NUMB PASK PDPK1 PELI1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRD PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SHC1 SIK2 SOCS1 SOCS3 TERT TRIM72 TUB TYK2 UBC UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID		5588	3667
HPRD ID		02710	00943
Ensembl ID		ENSG00000065675	ENSG00000169047
Uniprot IDs		Q04759	P35568
PDB IDs		1XJD 2ENJ 2ENN 2ENZ 2JED 4Q9Z 4RA5 5F9E	1IRS 1K3A 1QQG 2Z8C 5U1M 6BNT
Enriched GO Terms of Interacting Partners?
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