KDM4D and PPP1CC

Number of citations of the paper that reports this interaction (PubMedID 21382349)
28

Data Source:
BioGRID (two hybrid)

		KDM4D	PPP1CC
Description		lysine demethylase 4D	protein phosphatase 1 catalytic subunit gamma
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Pericentric Heterochromatin Site Of Double-strand Break Blood Microparticle	Protein Phosphatase Type 1 Complex Kinetochore Chromosome, Telomeric Region Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Focal Adhesion Nuclear Speck Midbody Cleavage Furrow Protein-containing Complex Dendritic Spine PTW/PP1 Phosphatase Complex Presynapse Glutamatergic Synapse
	Molecular Function	Damaged DNA Binding Protein Binding Chromatin DNA Binding Histone Demethylase Activity Histone H3-methyl-lysine-9 Demethylase Activity Metal Ion Binding Dioxygenase Activity	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Lamin Binding Protein C-terminus Binding Protein Phosphatase 1 Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation Chromatin Remodeling Histone H3-K9 Demethylation Positive Regulation Of Chromatin Binding Cellular Response To Ionizing Radiation Negative Regulation Of Histone H3-K9 Trimethylation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	MAPK Cascade Glycogen Metabolic Process Protein Dephosphorylation Cell Cycle Neuron Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Nucleocytoplasmic Transport Cell Division Positive Regulation Of Glial Cell Proliferation
Pathways		HDMs demethylate histones	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Triglyceride catabolism Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Circadian Clock RHO GTPases Activate Formins RAF activation Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs			9,10-Deepithio-9,10-Didehydroacanthifolicin Calyculin A Motuporin
Diseases
GWAS		Diabetic kidney disease ( 26305897)	Heart rate ( 23583979)
Interacting Genes		4 interacting genes: CEP76 LRRK2 PPP1CC TP53	131 interacting genes: AATK ABT1 ACAD8 AKAP11 ANKRD42 APIP APP ASH2L AURKA B4GAT1 BMPR2 BTBD10 C14orf180 C1QA C9orf50 CEP126 CLMN CLOCK CLTC CNST COPS5 CSNK1A1 CSNK1E CSNK2B CSRNP1 CSRNP2 CTSL CYFIP1 DACT1 DEAF1 DELEC1 DYNLT4 DYRK4 EIF2AK2 ELP4 ENKD1 FBXW11 FTL FXYD6 GLB1L GOLGA7 GSTZ1 HCFC1 HDAC6 HMGN1 IFTAP IL3RA INSYN1 JAK2 KCTD20 KDM4D KRCC1 LMTK2 MAP4K4 MAPT MYO16 NAPEPLD NEK2 NMT2 NONO NRBP1 NUAK1 PHACTR4 PHC1 PIAS1 POLR1F PPP1R11 PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R2B PPP1R2C PPP1R32 PPP1R35 PPP1R3A PPP1R3B PPP1R3C PPP1R3D PPP1R7 PPP1R8 PPP1R9A PPP1R9B PPP2R5C PRR16 RAF1 RB1 RIF1 RNF19B RORC RPL7 RPRD2 RRM1 RRP1B SDR39U1 SFRP1 SGCE SH3RF2 SHANK3 SMARCB1 SMG6 SPATC1L SPOCD1 STAM STARD9 STAU1 SUMO2 TACC2 TBC1D19 TEFM TEX36 TLX1 TLX3 TMEM120A TNS1 TOPBP1 TOR1AIP1 TP53 TP53BP2 TPRN TRA2A VSTM4 WBP11 YLPM1 YWHAZ ZDBF2 ZFYVE9 ZNF24 ZNF318 ZNF629 ZNF667
Entrez ID		55693	5501
HPRD ID		17169	08911
Ensembl ID		ENSG00000186280	ENSG00000186298
Uniprot IDs		Q6B0I6	A0A024RBP2 P36873
PDB IDs		3DXT 3DXU 4D6Q 4D6R 4D6S 4HON 4HOO 5F5A 5F5C 5FP4 5FP7 5FP8 5FP9 5FPA 5FPB 5PH0 5PH1 5PH2 5PH3 5PH4 5PH5 5PH6 5PH7 5PH8 5PH9 5PHA 5PHB 5PHC 5PHD 5PHE 5PHF 5PHG 5PHH 5PHI 5PHJ 5PHK 5PHL 5PHM 5PHN 5PHO 5PHP 5PHQ 5PHR 5PHS 5PHT 5PHU 5PHV 5PHW 5PHX 5PHY 5PHZ 5PI0 5PI1 5PI2 5PI3 5PI4 5PI5 5PI6 5PI7 5PI8 5PI9 5PIA 5PIB 5PIC 5PID 5PIE 5PIF 5PIG 5PIH 5PII 5PIJ 5PIK 5PIL 5PIM 5PIN 5PIO 5PIP 5PIQ 5PIR 5PIS 5PIT 5PIU 5PIV 5PIW 5PIX 5PIY 5PIZ 5PJ0 5PJ1 5PJ2 5PJ3 5PJ4 5PJ5 5PJ6 5PJ7 5PJ8 5PJ9 5PJA 5PJB 5PJC 5PJD 5PJE 5PJF 5PJG 5PJH 5PJI 5PJJ 5PJK 5PJL 5PJM 5PJN 5PJO 5PJP 5PJQ 5PJR 5PJS 5PJT 5PJU 5PJV 5PJW 5PJX 5PJY 5PJZ 5PK0 5PK1 5PK2 5PK3 5PK4 5PK5 5PK6 5PK7 5PK8 5PK9 5PKA 5PKB 5PKC 5PKD 5PKE 5PKF 5PKG 5PKH 5PKI 5PKJ 5PKK 5PKL 5PKM 5PKN 5PKO 5PKP 5PKQ 5PKR 5PKS 5PKT 5PKU 5PKV 5PKW 5PKX 5PKY 5PKZ 5PL0 5PL1 5PL2 5PL3 5PL4 5PL5 5PL6 5PL7 5PL8 5PL9 5PLA 5PLB 5PLC 5PLD 5PLE 5PLF 5PLG 5PLH 5PLI 5PLJ 5PLK 5PLL 5PLM 5PLN 5PLO 5PLP 5PLQ 5PLR 5PLS 5PLT 5PLU 5PLV 5PLW 5PLX 5PLY 5PLZ 5PM0 5PM1 5PM2 5PM3 5PM4 5PM5 5PM6 5PM7 5PM8 5PM9 5PMA 5PMB 5PMC 5PMD 5PME 5PMF 5PMG 5PMH 5PMI 5PMJ 5PMK 5PML 5PMM 5PMN 5PMO 5PMP 5PMQ 5PMR 5PMS 5PMT 5PMU 5PMV 5PMW 5PMX 5PMY 5PMZ 5PN0 5PN1 5PN2 5PN3 5PN4 5PN5 5PN6 5PN7 5PN8 5PN9 5PNA 5PNB 5PNC 5PND 5PNE 5PNF 5PNG 5PNH 5PNI 5PNJ 5PNK 5PNL 5PNM 5PNN 5PNO 5PNP 5PNQ 5PNR 5PNS 5PNU 5PNV 5PNW 6ETE 6ETG 6ETS 6ETT 6ETU 6ETV 6ETW 6F5Q 6F5R 6F5S 6F5T 6H0W 6H0X 6H0Y 6H0Z 6H10 6H11	1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3 5INB 5J28
Enriched GO Terms of Interacting Partners?
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