SYBU and CLASP1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SYBU	CLASP1
Description		syntabulin	cytoplasmic linker associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Microtubule Cytoplasmic Microtubule Integral Component Of Membrane Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Dense Body Axon Cytoplasm	Kinetochore Golgi Apparatus Centrosome Microtubule Organizing Center Kinetochore Microtubule Cytosol Spindle Microtubule Cytoplasmic Microtubule Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Centrosomal Corona Microtubule Plus-end Basal Cortex Mitotic Spindle
	Molecular Function	Protein Binding Microtubule Binding Syntaxin-1 Binding Kinesin Binding	Dystroglycan Binding Protein Binding Microtubule Binding Kinetochore Binding Microtubule Plus-end Binding
	Biological Process	Axonal Transport Of Mitochondrion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Synaptic Activity Synapse Maturation Anterograde Neuronal Dense Core Vesicle Transport	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Astral Microtubule Organization Microtubule Organizing Center Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Establishment Of Spindle Orientation Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Extracellular Matrix Disassembly Establishment Of Epithelial Cell Polarity Mitotic Spindle Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Ankle-brachial index ( 31388106) Schizophrenia x sex interaction ( 34099189)	Chloride levels ( 29403010) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Potassium levels ( 29403010) Triglyceride levels ( 32154731)
Interacting Genes		7 interacting genes: ARPC3 ATXN1 CLASP1 DISC1 EXOC1 KIF5B RPL29	12 interacting genes: CKAP5 JAKMIP2 MAP4 MAPRE1 MAPRE3 MARK3 MTNR1A MTNR1B PRKRA SRPK2 SYBU YWHAG
Entrez ID		55638	23332
HPRD ID		07902	09322
Ensembl ID		ENSG00000147642	ENSG00000074054
Uniprot IDs		B7Z4D2 Q9NX95	Q7Z460
PDB IDs			4K92 6MQ5 6MQ7
Enriched GO Terms of Interacting Partners?
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