CLASP1 and JAKMIP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CLASP1	JAKMIP2
Description		cytoplasmic linker associated protein 1	janus kinase and microtubule interacting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Golgi Apparatus Centrosome Microtubule Organizing Center Kinetochore Microtubule Cytosol Spindle Microtubule Cytoplasmic Microtubule Focal Adhesion Cell Cortex Membrane Cortical Microtubule Cytoskeleton Centrosomal Corona Microtubule Plus-end Basal Cortex Mitotic Spindle	Golgi Apparatus
	Molecular Function	Dystroglycan Binding Protein Binding Microtubule Binding Kinetochore Binding Microtubule Plus-end Binding	Protein Binding Microtubule Binding Kinase Binding
	Biological Process	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Vesicle Targeting Microtubule Nucleation Negative Regulation Of Microtubule Depolymerization Golgi Organization Mitotic Spindle Organization Establishment Or Maintenance Of Cell Polarity Exit From Mitosis Regulation Of Gastrulation Positive Regulation Of Epithelial Cell Migration Regulation Of Epithelial To Mesenchymal Transition Astral Microtubule Organization Microtubule Organizing Center Organization Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Microtubule Anchoring Establishment Of Mitotic Spindle Localization Positive Regulation Of Exocytosis Establishment Of Spindle Orientation Cell Division Negative Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Extracellular Matrix Disassembly Establishment Of Epithelial Cell Polarity Mitotic Spindle Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Fostamatinib
Diseases
GWAS		Chloride levels ( 29403010) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) HDL cholesterol x physical activity interaction (1df test) ( 30670697) HDL cholesterol x physical activity interaction (2df test) ( 30670697) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Potassium levels ( 29403010) Triglyceride levels ( 32154731)	Alcoholic chronic pancreatitis ( 28754779) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Sleep activity levels ( 33075057) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		12 interacting genes: CKAP5 JAKMIP2 MAP4 MAPRE1 MAPRE3 MARK3 MTNR1A MTNR1B PRKRA SRPK2 SYBU YWHAG	19 interacting genes: CCDC136 CCDC88B CLASP1 CLIP4 EFHC2 ELOA HGS HOMEZ KIF9 LINC00839 MRPL11 NAB2 NTAQ1 PIN1 PRPF31 SMARCE1 TRIM29 VPS52 ZNF263
Entrez ID		23332	9832
HPRD ID		09322	11090
Ensembl ID		ENSG00000074054	ENSG00000176049
Uniprot IDs		Q7Z460	Q96AA8
PDB IDs		4K92 6MQ5 6MQ7
Enriched GO Terms of Interacting Partners?
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