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PRKAA1 and TSC2
Number of citations of the paper that reports this interaction (PubMedID
14651849
)
1449
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology)
PRKAA1
TSC2
Description
protein kinase AMP-activated catalytic subunit alpha 1
TSC complex subunit 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Apical Plasma Membrane
Nuclear Speck
Axon
Dendrite
Nucleotide-activated Protein Kinase Complex
Neuronal Cell Body
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Histone Serine Kinase Activity
Protein-containing Complex Binding
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Tau Protein Binding
Tau-protein Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Protein Serine Kinase Activity
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Biological Process
Response To Hypoxia
Glucose Metabolic Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Autophagy
Signal Transduction
Positive Regulation Of Cell Population Proliferation
Lipid Biosynthetic Process
Response To UV
Cold Acclimation
Response To Gamma Radiation
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Response To Activity
Bile Acid And Bile Salt Transport
Wnt Signaling Pathway
Fatty Acid Oxidation
Response To Caffeine
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Oxidative Stress
Histone-serine Phosphorylation
Intracellular Signal Transduction
Bile Acid Signaling Pathway
Cellular Response To Glucose Starvation
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Glycolytic Process
Negative Regulation Of Glucosylceramide Biosynthetic Process
Negative Regulation Of Insulin Receptor Signaling Pathway
Rhythmic Process
Positive Regulation Of Skeletal Muscle Tissue Development
Negative Regulation Of Lipid Catabolic Process
Fatty Acid Homeostasis
Regulation Of Vesicle-mediated Transport
Motor Behavior
CAMKK-AMPK Signaling Cascade
Regulation Of Stress Granule Assembly
Neuron Cellular Homeostasis
Cellular Response To Hydrogen Peroxide
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Ethanol
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Organonitrogen Compound
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Energy Homeostasis
Regulation Of Bile Acid Secretion
Response To Camptothecin
Positive Regulation Of Mitochondrial Transcription
Positive Regulation Of Cellular Protein Localization
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Tubulin Deacetylation
Response To 17alpha-ethynylestradiol
Positive Regulation Of Peptidyl-lysine Acetylation
Neural Tube Closure
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Endocytosis
Heart Development
Protein Localization
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of TOR Signaling
Anoikis
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitophagy
Pathways
Macroautophagy
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Activation of AMPK downstream of NMDARs
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Drugs
Adenosine phosphate
Adenosine phosphate
ATP
Phenformin
Acetylsalicylic acid
Fostamatinib
Fostamatinib
Diseases
GWAS
Cardia gastric cancer (
26129866
)
Gastric cancer (
22037551
26098866
26129866
31383772
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Non-cardia gastric cancer (
26701879
26129866
)
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Interacting Genes
68 interacting genes:
ABI2
ACACA
AGAP2
BHLHE40
CAB39
CAMKK1
CDX4
CFTR
CHEK1
CRTC2
CTBP1
DVL2
EEF2K
EPM2A
FANCA
FNIP1
GATA1
GOLGA2
GRIK2
HDAC5
HMBOX1
HOMEZ
IKZF3
INO80E
KIF16B
KRT40
L3MBTL3
MDM4
MORC4
MTOR
MTUS2
PASK
PFKFB2
PHC2
PNMA5
PPM1A
PPM1E
PPM1F
PPP2CA
PRKAB1
PRKAB2
PRKAG1
PRKAG3
PSMD11
RACK1
RAD54B
RAF1
RBPMS
RFX6
RIMBP3
ROPN1
RPTOR
SRPK2
SSX2IP
STK11
THAP1
TLE5
TOMM34
TRIM27
TRIP6
TSC2
TSC22D4
TXNIP
UBXN11
ULK1
VPS37B
VPS52
ZBED1
59 interacting genes:
ACTN2
AKT1
AKT2
AKT3
ANKRD35
CALM1
CBY2
CCND1
CDKN1B
EEF1A1
ESR1
FBXL6
FBXW5
GAPDH
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
MKRN1
MRPL21
NEK1
PAM
PHLDB1
PICK1
PIN1
PLK2
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPL4
RPS6KA1
RPSA
SEPTIN4
SERPINI1
SFN
SLC13A3
SMAD2
SMAD3
SSC4D
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
USPL1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
5562
7249
HPRD ID
04115
01850
Ensembl ID
ENSG00000132356
ENSG00000103197
Uniprot IDs
Q13131
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D7Q2
PDB IDs
4RED
4RER
4REW
5EZV
6C9F
6C9G
6C9H
6C9J
7DL2
Enriched GO Terms of Interacting Partners
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