TSC2 and MRPL21

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		TSC2	MRPL21
Description		TSC complex subunit 2	mitochondrial ribosomal protein L21
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding	RNA Binding Structural Constituent Of Ribosome
	Biological Process	Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Heart Development Protein Localization Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Anoikis Protein Kinase B Signaling Positive Regulation Of GTPase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitophagy	Translation
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs
Diseases
GWAS		Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) White blood cell count ( 32888494)
Interacting Genes		59 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	2 interacting genes: ERCC6 TSC2
Entrez ID		7249	219927
HPRD ID		01850	14747
Ensembl ID		ENSG00000103197	ENSG00000197345
Uniprot IDs		B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D7Q2	A0A024R5G7 B4DXI4 Q7Z2W9
PDB IDs		7DL2	3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K
Enriched GO Terms of Interacting Partners?
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