PRR5-ARHGAP8 and SH3GL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PRR5-ARHGAP8	SH3GL1
Description		PRR5-ARHGAP8 readthrough	SH3 domain containing GRB2 like 1, endophilin A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Podosome Cytoplasm Cytosol Early Endosome Membrane Cell Projection Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function		Protein Binding Protein C-terminus Binding Lipid Binding SH3 Domain Binding Phosphatase Binding Beta-1 Adrenergic Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Cadherin Binding GTPase Binding
	Biological Process		Signal Transduction Central Nervous System Development Synaptic Vesicle Uncoating Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Endocytosis
Pathways			EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Body mass index ( 28552196) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Major depressive disorder ( 27777418) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Weight ( 28552196)	Hematocrit ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		4 interacting genes: CYGB GRB2 SH3GL1 ZMYND12	37 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PRR5-ARHGAP8 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 STK11 SYNJ1 VPS37C YWHAZ
Entrez ID		553158	6455
HPRD ID		18688	03462
Ensembl ID		ENSG00000248405	ENSG00000141985
Uniprot IDs		B1AHC3	Q6FGM0 Q99961
PDB IDs
Enriched GO Terms of Interacting Partners?
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