SH3GL1 and STK11

		SH3GL1	STK11
Description		SH3 domain containing GRB2 like 1, endophilin A2	serine/threonine kinase 11
Image		No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Early Endosome Membrane Cell Projection Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding SH3 Domain Binding Phosphatase Binding Beta-1 Adrenergic Receptor Binding Identical Protein Binding Transmembrane Transporter Binding Cadherin Binding GTPase Binding	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity Protein Serine Kinase Activity
	Biological Process	Signal Transduction Central Nervous System Development Synaptic Vesicle Uncoating Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Endocytosis	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Spermatogenesis Axonogenesis Negative Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Establishment Of Cell Polarity Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Cell Cycle Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Vesicle Transport Along Microtubule Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Red cell distribution width ( 32888494)	Asthma (childhood onset) ( 31036433) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Distal/Left-sided colorectal cancer ( 33632709) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900) Psychosis in Alzheimer's disease ( 22005930)
Interacting Genes		37 interacting genes: ARHGAP1 ARHGAP8 AXIN1 B3GAT1 CCDC50 CMTM5 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A FBXO32 GPKOW ITCH ITSN2 MAL2 MTA1 NUTM2F PDCD6IP PML PRB3 PRR5-ARHGAP8 PSMB1 PTPRO RHEX SCAMP5 SEPTIN8 SH2D4A SH3D19 SH3GL3 SOCS1 SPG21 STK11 SYNJ1 VPS37C YWHAZ	140 interacting genes: ABCB5 ADIPOR1 AKT1 ALDOB ANP32B APP ARAF ARG2 ARNT ATM AURKA BAP1 BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCDC180 CCND2 CCNE1 CD44 CDC14B CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYLC2 CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FAM98B FBP1 FBP2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A HRAS IGFBP3 KAT2A KDELR2 KLK7 LATS2 LEF1 LYPD3 MADCAM1 MAP2K1 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPK3 MAPRE1 MARK1 MARK2 MARK4 MDM2 MET MOB4 MOCS2 MT-ND2 MYC NANS NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PPP2CB PPP6R1 PRKAA1 PRKAA2 PRKACA PRSS50 PTEN RASA1 RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SERPINB5 SH3GL1 SIK1 SIRT1 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB STX17 TBC1D23 TDRD7 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TRMO TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 XPA YWHAG ZNF189 ZNF195 ZNF510
Entrez ID		6455	6794
HPRD ID		03462	03740
Ensembl ID		ENSG00000141985	ENSG00000118046
Uniprot IDs		Q6FGM0 Q99961	A0A0S2Z4D1 Q15831
PDB IDs			2WTK 4ZDR 5WXN
Enriched GO Terms of Interacting Partners?
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