MACO1 and NR4A3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MACO1	NR4A3
Description		macoilin 1	nuclear receptor subfamily 4 group A member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Integral Component Of Membrane Axon Rough Endoplasmic Reticulum Membrane Nuclear Membrane Neuron Projection Terminus Synapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Molecular_function Protein Binding Microtubule Binding Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity
	Biological Process	Chemotaxis Brain Development Neuronal Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Gastrulation Pyruvate Oxidation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glucose Transmembrane Transport Intracellular Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Mast Cell Cytokine Production Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Mast Cell Degranulation Steroid Hormone Mediated Signaling Pathway Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Positive Regulation Of Monocyte Aggregation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior
Pathways		RHOA GTPase cycle RHOC GTPase cycle	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs			Dasatinib
Diseases
GWAS		LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)	Dental caries ( 23064961) Depression in smokers ( 30219690) Eosinophil percentage of white cells ( 32888494) Lung cancer ( 28604730) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 34127860)
Interacting Genes		23 interacting genes: CRCT1 HOXA1 KRTAP5-2 KRTAP5-7 LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3E LINGO1 MEI4 MEOX2 NBPF19 NOTCH2NLA NR4A3 POTEB3 SMAD9 SMCP SRPK2 TMEM190 ZNF655	43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330
Entrez ID		55219	8013
HPRD ID		13340	02766
Ensembl ID		ENSG00000204178	ENSG00000119508
Uniprot IDs		Q8N5G2	A0A024R168 Q92570
PDB IDs
Enriched GO Terms of Interacting Partners?
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