RIC8B and GNAS

Number of citations of the paper that reports this interaction (PubMedID 12652642)
25

Data Source:
HPRD (in vitro, two hybrid)

		RIC8B	GNAS
Description		RIC8 guanine nucleotide exchange factor B	GNAS complex locus
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex	Cytosol Heterotrimeric G-protein Complex Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity	G Protein-coupled Receptor Binding GTPase Activity Insulin-like Growth Factor Receptor Binding Protein Binding GTP Binding Adenylate Cyclase Activator Activity G-protein Beta/gamma-subunit Complex Binding Beta-2 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Mu-type Opioid Receptor Binding Ionotropic Glutamate Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Catalytic Activity	Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Chemical Stimulus Regulation Of Cyclase Activity Developmental Growth Bone Development Platelet Aggregation Positive Regulation Of Cold-induced Thermogenesis
Pathways			Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production
Drugs			Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Diseases
GWAS		Adiponectin levels ( 31178129) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Night sleep phenotypes ( 27126917) PR interval ( 32439900) Serum alkaline phosphatase levels ( 33547301 33339817) Severe influenza A (H1N1) infection ( 26379185) Social autistic-like traits ( 24133439) Triglyceride levels ( 29083408 32203549 28334899 32154731) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Birth weight ( 31043758) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Colorectal cancer ( 30529582) Creatinine levels ( 29124443) Diastolic blood pressure ( 21909115 29403010 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) DNA methylation (variation) ( 23725790) Estimated glomerular filtration rate ( 31152163 31015462 29124443) HDL cholesterol levels ( 32203549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 21909115) Hyperuricemia ( 29124443) Mean arterial pressure ( 29403010) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Renal function-related traits (BUN) ( 22797727) Response to diuretic therapy in hypertension ( 23753411) Serum uric acid levels ( 29124443) Sulfasalazine-induced agranulocytosis ( 28762467) Systolic blood pressure ( 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 30297969 32499647) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 26785701)
Interacting Genes		4 interacting genes: CKAP4 GNAQ GNAS LRP1	42 interacting genes: ADCY2 ADCY5 ADCY6 ADORA1 ADRB2 ADRB3 AVPR2 AXIN1 CALM1 CAV3 CHEK2 CHRM3 CRHR1 CYSLTR2 DRD5 EGFR FZD7 GCGR GLP1R GNB1 GNGT1 HTR6 LHB LHCGR MSANTD3 MTNR1B NUCB1 NUCB2 OPTN PANX1 PTGDR PTGIR PTGIS RGS2 RIC8A RIC8B RXFP3 SNX13 TBXA2R TSHR TTC1 VIPR1
Entrez ID		55188	2778
HPRD ID		16452	00761
Ensembl ID		ENSG00000111785	ENSG00000087460
Uniprot IDs		A0A024RBG9 B7WPL0 Q9NVN3	A0A0S2Z3H8 A0A0S2Z3S5 A0A590UJF0 B0AZR9 O95467 P63092 P84996 Q14455 Q5FWY2 Q5JWD1 Q5JWF2
PDB IDs			5G53 5UZ7 5VAI 6AU6 6B3J 6E3Y 6E67 6EG8 6GDG 6LI3 6LMK 6LPB 6M1H 6M1I 6NI3 6NIY 6ORV 6P9X 6P9Y 6PB0 6PB1 6UUN 6UUS 6UVA 6VCB 6VN7 6WHC 6WI9 6WPW 6WZG 6X18 6X19 6X1A 6XOX 7BW0 7BZ2 7C2E 7CFM 7CFN 7CKW 7CKX 7CKY 7CKZ 7CRH 7CZ5 7D3S 7D7M 7DHI 7DHR 7JV5 7JVP 7LCI
Enriched GO Terms of Interacting Partners?
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