EPN3 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		EPN3	RNF8
Description		epsin 3	ring finger protein 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Plasma Membrane Clathrin-coated Pit Extrinsic Component Of Plasma Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding EH Domain Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Endocytosis	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Hip index ( 34021172)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		11 interacting genes: DAZAP2 FAM168A LAPTM5 LITAF MID1 NTAQ1 RNF11 RNF8 RPS27A TRIM26 UBC	77 interacting genes: AMOTL2 BLM C2CD6 CALCOCO1 CCDC14 CCDC50 CCDC85B CEP44 CEP85 CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A KIF24 KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCNA PCYT1A PGRMC2 PICK1 PNMA2 POLD4 PSMB1 RBFOX2 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		55040	9025
HPRD ID		06272	11521
Ensembl ID		ENSG00000049283	ENSG00000112130
Uniprot IDs		Q9H201	O76064
PDB IDs			2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?
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