PPP2R3C and SMG9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PPP2R3C	SMG9
Description		protein phosphatase 2 regulatory subunit B''gamma	SMG9 nonsense mediated mRNA decay factor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Centrosome Spindle Cytosol	Cytosol
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization B Cell Homeostasis Regulation Of Antimicrobial Humoral Response Cortical Cytoskeleton Organization Activation Of Protein Kinase Activity Regulation Of Dephosphorylation T Cell Homeostasis Positive Regulation Of B Cell Differentiation Spleen Development Regulation Of Mitochondrial Depolarization	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Eye Development In Utero Embryonic Development Brain Development Heart Development
Pathways			Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Atopic dermatitis ( 26482879) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal carcinoma in primary sclerosing cholangitis ( 28779025) Lymphocyte counts ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494)	Lymphocyte counts ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010)
Interacting Genes		15 interacting genes: CCDC146 CCDC33 CMTM5 ENKD1 FAM161A FAM161B HSPB1 IKBKB MOAP1 MTNR1A POLR1C PRPF31 RTN3 SMG9 TRIM14	39 interacting genes: AGTRAP AK8 ARFIP2 CCDC57 CEP76 CMTM4 CTAG1A CTAG1B DGAT2L6 FNTB GOLGA2 GSG1 HSF2BP INCA1 KRT31 KRT34 KRTAP10-8 MTUS2 NFKBID PFDN5 PHF1 PLEKHG4 PNMA3 PPP2R3C PRKAR1B RASSF10 REL SLC17A9 SLC50A1 SYP TCF4 TRAF2 TRIM23 TRIM27 TRIP6 TSC1 TTC19 ZMYND12 ZNF655
Entrez ID		55012	56006
HPRD ID		12622	07800
Ensembl ID		ENSG00000092020	ENSG00000105771
Uniprot IDs		Q969Q6	A0A024R0Q0 Q9H0W8
PDB IDs			6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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