EXD3 and INPP5E

		EXD3	INPP5E
Description		exonuclease 3'-5' domain containing 3	inositol polyphosphate-5-phosphatase E
Image		No pdb structure
GO Annotations	Cellular Component		Ruffle Nucleus Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Axoneme Golgi Cisterna Membrane
	Molecular Function	Nucleic Acid Binding Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
	Biological Process	Nucleic Acid Phosphodiester Bond Hydrolysis	Phosphatidylinositol Biosynthetic Process Biological_process Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Translation Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Negative Regulation Of Protein Localization To Cilium
Pathways			Synthesis of PIPs at the Golgi membrane ARL13B-mediated ciliary trafficking of INPP5E
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Chronotype ( 30696823 27494321) Loneliness ( 27629369) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Multisite chronic pain ( 33830993 31194737) Platelet distribution width ( 32888494)	Crohn's disease ( 28067908) Granulocyte count ( 27863252) Hemoglobin A1c levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Red cell distribution width ( 32888494) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 32888494 27863252)
Interacting Genes		3 interacting genes: DAZAP2 INPP5E PLSCR1	3 interacting genes: EXD3 KTN1 YWHAG
Entrez ID		54932	56623
HPRD ID		07906	17151
Ensembl ID		ENSG00000187609	ENSG00000148384
Uniprot IDs		Q8N9H8	Q9NRR6
PDB IDs			2XSW
Enriched GO Terms of Interacting Partners?
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