INPP5E

Description		inositol polyphosphate-5-phosphatase E
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GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Axoneme Golgi Cisterna Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
	Biological Process	Phosphatidylinositol Biosynthetic Process Biological_process Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Translation Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Negative Regulation Of Protein Localization To Cilium
Pathways		Synthesis of PIPs at the Golgi membrane ARL13B-mediated ciliary trafficking of INPP5E
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Granulocyte count ( 27863252) Hemoglobin A1c levels ( 29403010) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Liver enzyme levels (alkaline phosphatase) ( 33972514) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Red cell distribution width ( 32888494) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 32888494 27863252)
Interacting Genes		3 interacting genes: EXD3 KTN1 YWHAG
Entrez ID		56623
HPRD ID		17151
Ensembl ID		ENSG00000148384
Uniprot IDs		Q9NRR6
PDB IDs		2XSW
Enriched GO Terms of Interacting Partners?
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