DUS2 and NECTIN2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		DUS2	NECTIN2
Description		dihydrouridine synthase 2	nectin cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome
	Molecular Function	TRNA Binding Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding FMN Binding TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding NADPH Binding TRNA-dihydrouridine20 Synthase Activity	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	TRNA Dihydrouridine Synthesis Negative Regulation Of Catalytic Activity Negative Regulation Of Cell Death	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways		tRNA modification in the nucleus and cytosol	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Eosinophil counts ( 32888494) Hemoglobin levels ( 32327693) Schizophrenia ( 29483656)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: EPRS1 NECTIN2 SMN1 TK1	37 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 PVR RGS20 SIAH1 TCF4 TGM1 TIGIT USP53
Entrez ID		54920	5819
HPRD ID		08624	02879
Ensembl ID		ENSG00000167264	ENSG00000130202
Uniprot IDs		A0A024R6Z7 B4DKP8 E7EUN9 Q9NX74	Q92692
PDB IDs		4WFS 4WFT 4XP7 5OC4 5OC5 5OC6 6EI8 6EZA 6EZB 6EZC 6F00	3R0N 4DFH 4DFI 4HZA 5V52
Enriched GO Terms of Interacting Partners?
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