SPDL1 and PPP1R18

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		SPDL1	PPP1R18
Description		spindle apparatus coiled-coil protein 1	protein phosphatase 1 regulatory subunit 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spindle Pole Outer Kinetochore Nucleus Microtubule Organizing Center Cytosol	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding Enzyme Binding Kinetochore Binding	Actin Binding Protein Binding Phosphatase Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Signaling Cell Migration Protein Localization To Kinetochore Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Bipolar disorder x sex interaction ( 34099189)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 33909500) Hemoglobin levels ( 32327693) Lung cancer ( 28604730)
Interacting Genes		10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45	80 interacting genes: ABRA ACTN3 BICD2 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCDC88B CDR2L CEP70 COG6 DES DZIP1 EIF3L FAM9B FHL5 FSD2 GCC1 GFAP GMCL1 GOLGA2 GOLGA6L9 GOPC GRIPAP1 GTPBP3 HAP1 HOMER3 HOOK2 HSF2BP IKZF3 KASH5 KCTD9 KRT13 KRT15 KRT16 KRT19 KRT27 KRT31 KRT33B KRT34 KRT36 KRT40 LDOC1 LZTS1 LZTS2 MAD1L1 MAPK1 MEOX2 MID2 MRPL38 MTUS2 NACA NEFL PDE4DIP PIBF1 PLEKHF2 PPP1CA PPP1CC PPP1R13B PRPH SORBS3 SPDL1 STX11 TCF4 TEX11 TFIP11 TRAF2 TRIM23 TRIM27 TRIM54 TRIM62 TRIM69 TSC1 TSGA10 VIM VPS52 ZMYND12 ZRANB1
Entrez ID		54908	170954
HPRD ID		08623	11172
Ensembl ID		ENSG00000040275	ENSG00000146112
Uniprot IDs		Q96EA4	A0A024RCJ8 Q6NYC8
PDB IDs
Enriched GO Terms of Interacting Partners?
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