POU2F2 and HMGB2

Number of citations of the paper that reports this interaction (PubMedID 7720710)
77

Data Source:
HPRD (in vitro, in vivo)

		POU2F2	HMGB2
Description		POU class 2 homeobox 2	high mobility group box 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Chromatin Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Four-way Junction DNA Binding Transcription Cis-regulatory Region Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Positive Regulation Of Interleukin-6 Production Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Negative Regulation Of Gene Expression Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Eosinophil counts ( 32888494) Meat-related diet ( 32066663) Monocyte count ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016)
Interacting Genes		15 interacting genes: AR ESR1 GAPDH HMGA1 HMGB2 MNAT1 MSX2 NR2F1 NR3C1 PGR POU2AF1 RXRA TBP TXNRD1 XRCC6	47 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A COMMD1 CREBBP CSNK1A1 EIF1 FBXO7 FLNA GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 MYL6 NAP1L1 NCBP3 NEXN NOP53 NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 RPS28 SAMM50 SET SNAPIN TERT TP53 TSNAX U2AF1 UHRF2 ZNF428 ZNF622 ZNF668
Entrez ID		5452	3148
HPRD ID		01251	01229
Ensembl ID		ENSG00000028277	ENSG00000164104
Uniprot IDs		B5ME60 H0YLL6 P09086	P26583
PDB IDs		1HDP
Enriched GO Terms of Interacting Partners?
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