POMC and MC1R

Number of citations of the paper that reports this interaction (PubMedID 11041375)
38

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		POMC	MC1R
Description		proopiomelanocortin	melanocortin 1 receptor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development UV Protection Positive Regulation Of Protein Kinase A Signaling Regulation Of Metabolic Process Sensory Perception Of Pain Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Kinase B Signaling UV-damage Excision Repair Positive Regulation Of Protein Kinase C Signaling
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Loperamide Etorphine Dihydromorphine	Afamelanotide CZEN 002 Bremelanotide
Diseases
GWAS		Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)	Basal cell carcinoma ( 21700618 31174203 27539887) Black vs. non-black hair color ( 26184321) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798) Facial pigmentation ( 25705849) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 29662168) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Melanoma ( 21983787 28212542 24980573 19578364) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-melanoma skin cancer ( 23548203 29739929) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Perceived skin darkness ( 25963972) Red vs non-red hair color ( 17952075 26184321) Red vs. brown/black hair color ( 30531825) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 17952075 25963972) Squamous cell carcinoma ( 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 27723757 22561518) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		28 interacting genes: ABI2 APP ATP6V0D2 BHLHA9 C1orf109 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN	4 interacting genes: ASIP ICAM1 MC4R POMC
Entrez ID		5443	4157
HPRD ID		01462	01118
Ensembl ID		ENSG00000115138	ENSG00000258839
Uniprot IDs		P01189	Q01726 Q1JUL4
PDB IDs		4XNH 4XPD 4Y49 6TUB
Enriched GO Terms of Interacting Partners?
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