POMC and HLA-DRB3

Number of citations of the paper that reports this interaction (PubMedID 7477400)
129

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		POMC	HLA-DRB3
Description		proopiomelanocortin	major histocompatibility complex, class II, DR beta 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Secretory Granule Secretory Granule Lumen	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Hormone Activity Protein Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Type 1 Melanocortin Receptor Binding	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Neuropeptide Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Calcium-mediated Signaling Regulation Of Appetite Negative Regulation Of Tumor Necrosis Factor Production Cellular Pigmentation Glucose Homeostasis Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glycogen Metabolic Process Response To Melanocyte-stimulating Hormone Regulation Of Corticosterone Secretion	Adaptive Immune Response Immunoglobulin Production Involved In Immunoglobulin-mediated Immune Response Myeloid Dendritic Cell Antigen Processing And Presentation Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Pathways		Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes obesity and POMCD Interleukin-4 and Interleukin-13 signaling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes ADORA2B mediated anti-inflammatory cytokines production	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs		Loperamide Etorphine Dihydromorphine	1D09C3 Coccidioides immitis spherule
Diseases
GWAS		Body mass index ( 26426971 23669352 20935630) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 28067908) Height ( 28552196 23563607 18391951) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Obesity ( 23563607) Pubertal anthropometrics ( 23449627) Red vs. brown/black hair color ( 30531825) Type 1 diabetes ( 21980299)	Plantar warts ( 28928442)
Interacting Genes		28 interacting genes: ABI2 APP ATP6V0D2 BHLHA9 C1orf109 CCDC102B ESRRG FGF10 GLYCTK HDDC2 HLA-DRB3 HSF2BP KLHL42 MC1R MC2R MC3R MC4R MC5R MEP1A MKRN3 NFKBID NRDC NTAQ1 OAZ3 PAM SUOX TXN2 VTN	4 interacting genes: CDCA8 CTAG1B MAP3K13 POMC
Entrez ID		5443	3125
HPRD ID		01462	09985
Ensembl ID		ENSG00000115138
Uniprot IDs		P01189	A0A4D6G1L1 P79483
PDB IDs		4XNH 4XPD 4Y49 6TUB	2Q6W 3C5J 4H1L
Enriched GO Terms of Interacting Partners?
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