SEPTIN5 and PFN2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SEPTIN5	PFN2
Description		septin 5	profilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site	Cytoplasm Cytoskeleton Extracellular Exosome
	Molecular Function	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity
	Biological Process	Synaptic Vesicle Targeting Regulation Of Exocytosis Adult Behavior Cellular Protein Localization Social Behavior Cytoskeleton-dependent Cytokinesis Regulation Of Synaptic Vesicle Exocytosis	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways			Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			Triglyme Pentaglyme
Diseases
GWAS			Fish- and plant-related diet ( 32066663)
Interacting Genes		24 interacting genes: APP CDK5R1 DDIT4L KAT7 KIDINS220 LSM8 MAGEA2 MAGEA2B MAPK6 MYOG PFN2 PLEKHF2 PRKN PRODH SEPTIN1 SEPTIN11 SEPTIN12 SEPTIN2 SEPTIN4 SEPTIN7 SEPTIN8 SPG21 STX1A STX4	34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		5413	5217
HPRD ID		04100	01451
Ensembl ID		ENSG00000184702	ENSG00000070087
Uniprot IDs		Q99719 X5DNA9	P35080
PDB IDs			1D1J
Enriched GO Terms of Interacting Partners?
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