PFN2 and FHOD1

Number of citations of the paper that reports this interaction (PubMedID 12677009)
13

Data Source:
HPRD (two hybrid, in vitro)

		PFN2	FHOD1
Description		profilin 2	formin homology 2 domain containing 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome	Stress Fiber Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Intercalated Disc Membrane Bleb
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP Hydrolysis Activity	Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association Actin Filament Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Nuclear Migration Cortical Actin Cytoskeleton Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Actin Filament Network Formation Establishment Of Centrosome Localization
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	22 interacting genes: ACTA1 ACTG1 APC BBS1 BBS2 BBS4 BBS7 CR2 EXOSC8 GRB2 LNPEP NCOA6 NLGN3 PFN2 PPARG PRKG1 RAC1 RANBP2 RNF5 TRIM21 YWHAZ ZMYND8
Entrez ID		5217	29109
HPRD ID		01451	06049
Ensembl ID		ENSG00000070087	ENSG00000135723
Uniprot IDs		P35080	A0A068F7M9 Q9Y613
PDB IDs		1D1J	3DAD 6XF1 6XF2
Enriched GO Terms of Interacting Partners?
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