PLAT and SERPING1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PLAT	SERPING1
Description		plasminogen activator, tissue type	serpin family G member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Secretory Granule Apical Part Of Cell Collagen-containing Extracellular Matrix Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Phosphoprotein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Response To Hypoxia Cellular Protein Modification Process Proteolysis Blood Coagulation Smooth Muscle Cell Migration Plasminogen Activation Fibrinolysis Negative Regulation Of Proteolysis Platelet-derived Growth Factor Receptor Signaling Pathway Prevention Of Polyspermy Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission	Negative Regulation Of Complement Activation, Lectin Pathway Complement Activation, Classical Pathway Aging Blood Coagulation Blood Circulation Negative Regulation Of Endopeptidase Activity Fibrinolysis Innate Immune Response
Pathways		Signaling by PDGF Dissolution of Fibrin Clot	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade
Drugs		Aminocaproic acid Iloprost Human C1-esterase inhibitor 5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID Dexibuprofen Conestat alfa	PPL-100 Copper
Diseases
GWAS		Blood protein levels ( 30072576) Plasma plasminogen activator levels ( 24578379) Systemic lupus erythematosus ( 28714469)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		37 interacting genes: ANXA2 APP BAG4 CALR CKAP4 CLEC3B CRABP1 CRTC1 DDHD2 EIF4EBP1 F10 FGA FN1 GML GRIN1 HMGB1 KRT8 LAMA1 LAMA3 LRP1 LRP1B MAPK1 MAPK3 MTDH PDGFC PLAU PLG PPP2CB PVR SART1 SERPINA5 SERPINE1 SERPING1 SERPINI1 SLC28A2 SPARC VDAC1	16 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		5327	710
HPRD ID		01419	06033
Ensembl ID		ENSG00000104368	ENSG00000149131
Uniprot IDs		B4DN26 P00750	E9KL26 P05155
PDB IDs		1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN 5BRR 5ZLZ	1M6Q 2OAY 5DU3 5DUQ
Enriched GO Terms of Interacting Partners?
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