SERPINI1 and TSC2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		SERPINI1	TSC2
Description		serpin family I member 1	TSC complex subunit 2
Image
GO Annotations	Cellular Component	Extracellular Space Secretory Granule Lumen Neuronal Cell Body Perikaryon Cytoplasmic Vesicle Lumen Extracellular Exosome	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Postsynaptic Density Membrane TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	GTPase Activator Activity Protein Binding Phosphatase Binding Small GTPase Binding Protein Homodimerization Activity Hsp90 Protein Binding
	Biological Process	Central Nervous System Development Peripheral Nervous System Development Negative Regulation Of Endopeptidase Activity Positive Regulation Of Neuron Projection Development Regulation Of Cell Adhesion	Neural Tube Closure Negative Regulation Of Protein Kinase Activity Protein Import Into Nucleus Endocytosis Heart Development Protein Localization Negative Regulation Of Cell Population Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Vesicle-mediated Transport Positive Regulation Of Macroautophagy Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of TOR Signaling Anoikis Protein Kinase B Signaling Positive Regulation Of GTPase Activity Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Mitophagy
Pathways			Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs
Drugs
Diseases
GWAS		Eye color (saturation) ( 30664655) Fast beta electroencephalogram ( 28070124) Heart rate ( 23534349) Height ( 18391951) Hip circumference adjusted for BMI ( 28552196) Metabolite levels ( 23823483) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655)	Major depressive disorder ( 29317602) Obesity-related traits ( 23251661) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: PLAT PLG TSC2	59 interacting genes: ACTN2 AKT1 AKT2 AKT3 ANKRD35 CALM1 CBY2 CCND1 CDKN1B EEF1A1 ESR1 FBXL6 FBXW5 GAPDH GRB2 GSK3B LNX1 MAPK1 MAPK3 MAPKAPK2 MDFI MKRN1 MRPL21 NEK1 PAM PHLDB1 PICK1 PIN1 PLK2 PPP2CA PRKAA1 PTK2 PTPN11 RAB5A RABEP1 RHEB RPL4 RPS6KA1 RPSA SEPTIN4 SERPINI1 SFN SLC13A3 SMAD2 SMAD3 SSC4D SUPT6H TK1 TRIM55 TRIM63 TSC1 UBE3A USPL1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5274	7249
HPRD ID		03901	01850
Ensembl ID		ENSG00000163536	ENSG00000103197
Uniprot IDs		A0A0S2Z455 Q99574	B3KWH7 H3BMQ0 P49815 Q5HYF7 X5D7Q2
PDB IDs		3F02 3F5N 3FGQ	7DL2
Enriched GO Terms of Interacting Partners?
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