PDK2 and VSIG4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		PDK2	VSIG4
Description		pyruvate dehydrogenase kinase 2	V-set and immunoglobulin domain containing 4
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Pyruvate Dehydrogenase Complex	Integral Component Of Membrane Protein-containing Complex
	Molecular Function	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity	Complement Component C3b Binding Protein Binding
	Biological Process	Glucose Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Complement Activation, Alternative Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Negative Regulation Of Macrophage Activation Negative Regulation Of Complement Activation, Alternative Pathway
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE
Diseases
GWAS			Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		11 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 MAP3K8 PDHA1 PDHX PDK1 SGK1 VSIG4	9 interacting genes: AP2B1 APP C3 FATE1 JAGN1 PDK2 POLE TRIM72 VAMP5
Entrez ID		5164	11326
HPRD ID		03955	02286
Ensembl ID		ENSG00000005882	ENSG00000155659
Uniprot IDs		Q15119	Q9Y279
PDB IDs		2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P 6LIL 6LIN 6LIO 6TMP 6TMQ 6TMZ 6TN0 6TN2	2ICC 2ICE 2ICF 5IMK 5IML
Enriched GO Terms of Interacting Partners?
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