VSIG4 and PDK2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		VSIG4	PDK2
Description		V-set and immunoglobulin domain containing 4	pyruvate dehydrogenase kinase 2
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GO Annotations	Cellular Component	Integral Component Of Membrane Protein-containing Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Complement Component C3b Binding Protein Binding	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Complement Activation, Alternative Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Negative Regulation Of Macrophage Activation Negative Regulation Of Complement Activation, Alternative Pathway	Glucose Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs			4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE
Diseases
GWAS		Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		9 interacting genes: AP2B1 APP C3 FATE1 JAGN1 PDK2 POLE TRIM72 VAMP5	11 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 MAP3K8 PDHA1 PDHX PDK1 SGK1 VSIG4
Entrez ID		11326	5164
HPRD ID		02286	03955
Ensembl ID		ENSG00000155659	ENSG00000005882
Uniprot IDs		Q9Y279	Q15119
PDB IDs		2ICC 2ICE 2ICF 5IMK 5IML	2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P 6LIL 6LIN 6LIO 6TMP 6TMQ 6TMZ 6TN0 6TN2
Enriched GO Terms of Interacting Partners?
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