PDGFA and FURIN

Number of citations of the paper that reports this interaction (PubMedID 12670890)
25

Data Source:
HPRD (in vivo)

		PDGFA	FURIN
Description		platelet derived growth factor subunit A	furin, paired basic amino acid cleaving enzyme
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Microvillus Cell Surface Platelet Alpha Granule Lumen	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Integral Component Of Golgi Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding Growth Factor Receptor Binding	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding
	Biological Process	Angiogenesis Cell Activation Hair Follicle Development Positive Regulation Of Mesenchymal Cell Proliferation Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Wounding Animal Organ Morphogenesis Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Smooth Muscle Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Wound Healing Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Skin Development Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Regulation Of Branching Involved In Salivary Gland Morphogenesis By Epithelial-mesenchymal Signaling Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Glomerular Mesangial Cell Proliferation Embryonic Lung Development Regulation Of DNA Biosynthetic Process	Blastocyst Formation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signal Peptide Processing Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Protein Processing Peptide Hormone Processing Viral Life Cycle Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Zymogen Activation Regulation Of Cholesterol Transport Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity Dibasic Protein Processing Positive Regulation Of Transforming Growth Factor Beta1 Activation Amyloid Fibril Formation
Pathways		Non-integrin membrane-ECM interactions	Signaling by NODAL Collagen degradation Collagen degradation Elastic fibre formation Activation of Matrix Metalloproteinases Removal of aminoterminal propeptides from gamma-carboxylated proteins NGF processing Synthesis and processing of ENV and VPU Signaling by PDGF Pre-NOTCH Processing in Golgi TGF-beta receptor signaling activates SMADs Uptake and function of anthrax toxins Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes CD163 mediating an anti-inflammatory response Potential therapeutics for SARS Attachment and Entry Amyloid fiber formation
Drugs			Capric acid
Diseases
GWAS		Male-pattern baldness ( 28196072)	Age at first sexual intercourse ( 27089180 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) General risk tolerance (MTAG) ( 30643258) Hypertension ( 21909115 30487518) Ischemic stroke ( 29531354) Left-handedness ( 32989287) Mean arterial pressure ( 27618448 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656 30285260) Stroke ( 29531354) Systolic blood pressure ( 26390057 28135244 21909115 29403010 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 32888494)
Interacting Genes		17 interacting genes: A2M ASPH COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 DUSP3 FURIN HSPG2 MBD3 MDFI PDAP1 PDGFRA SPARC	38 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 ASH2L BACE1 CNMD COL23A1 DSG3 EDA FES FGF2 FLNA FLNC IDH2 IL1B ITM2C LRP1 MMP14 NAGPA NOTCH1 NPC1 NUCB2 PACS1 PDE4D PDGFA PELO PMCH PRB4 SERPINB8 SORCS1 SORL1 TMOD3 TNFSF13 VWF ZP3 ZP4
Entrez ID		5154	5045
HPRD ID		01424	00653
Ensembl ID		ENSG00000197461	ENSG00000140564
Uniprot IDs		P04085	A0A024RC70 P09958
PDB IDs		3MJK	4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD 6YD2 6YD3 6YD4 6YD7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?