FURIN and FGF2

		FURIN	FGF2
Description		furin, paired basic amino acid cleaving enzyme	fibroblast growth factor 2
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Golgi Lumen Trans-Golgi Network Plasma Membrane Cell Surface Endosome Membrane Membrane Trans-Golgi Network Transport Vesicle Integral Component Of Golgi Membrane Membrane Raft Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Cytoplasm
	Molecular Function	Protease Binding Endopeptidase Activity Serine-type Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Peptide Binding Metal Ion Binding Nerve Growth Factor Binding	Fibroblast Growth Factor Receptor Binding Cytokine Activity Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Chemokine Binding Nuclear Receptor Coactivator Activity Chemoattractant Activity Identical Protein Binding Receptor-receptor Interaction
	Biological Process	Blastocyst Formation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signal Peptide Processing Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Endopeptidase Activity Protein Processing Peptide Hormone Processing Viral Life Cycle Viral Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Zymogen Activation Regulation Of Cholesterol Transport Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nerve Growth Factor Production Negative Regulation Of Nerve Growth Factor Production Negative Regulation Of Transforming Growth Factor Beta1 Production Secretion By Cell Regulation Of Protein Catabolic Process Peptide Biosynthetic Process Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Endopeptidase Activity Dibasic Protein Processing Positive Regulation Of Transforming Growth Factor Beta1 Activation Amyloid Fibril Formation	Branching Involved In Ureteric Bud Morphogenesis Organ Induction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Chemotaxis Signal Transduction Ras Protein Signal Transduction Nervous System Development Aging Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Animal Organ Morphogenesis Glial Cell Differentiation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Fibroblast Migration Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Substantia Nigra Development Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Cell Differentiation Hyaluronan Catabolic Process Lung Development Regulation Of Cell Migration Inositol Phosphate Biosynthetic Process Paracrine Signaling Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Positive Regulation Of Cell Fate Specification Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Osteoblast Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Retinal Cell Programmed Cell Death Embryonic Morphogenesis Response To Axon Injury Stem Cell Development Positive Regulation Of Epithelial Cell Proliferation Positive Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Cycle Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Corticotropin Hormone Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Negative Regulation Of Cell Death Chondroblast Differentiation Mammary Gland Epithelial Cell Differentiation Angiogenesis Involved In Coronary Vascular Morphogenesis Negative Regulation Of Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Stem Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Tube Formation Positive Regulation Of Vascular Endothelial Cell Proliferation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis
Pathways		Signaling by NODAL Collagen degradation Collagen degradation Elastic fibre formation Activation of Matrix Metalloproteinases Removal of aminoterminal propeptides from gamma-carboxylated proteins NGF processing Synthesis and processing of ENV and VPU Signaling by PDGF Pre-NOTCH Processing in Golgi TGF-beta receptor signaling activates SMADs Uptake and function of anthrax toxins Formation of the cornified envelope Assembly of active LPL and LIPC lipase complexes CD163 mediating an anti-inflammatory response Potential therapeutics for SARS Attachment and Entry Amyloid fiber formation	PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Syndecan interactions Non-integrin membrane-ECM interactions Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 IIIa TM Signaling by FGFR3 point mutants in cancer
Drugs		Capric acid	Sucralfate Pentosan polysulfate Sirolimus Heparin 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid ABT-510
Diseases
GWAS		Age at first sexual intercourse ( 27089180 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 32469254 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) General risk tolerance (MTAG) ( 30643258) Hypertension ( 21909115 30487518) Ischemic stroke ( 29531354) Left-handedness ( 32989287) Mean arterial pressure ( 27618448 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Myocardial infarction ( 26343387) Neutrophil count ( 32888494) Offspring birth weight ( 31043758) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 25056061 29483656 30285260) Stroke ( 29531354) Systolic blood pressure ( 26390057 28135244 21909115 29403010 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White blood cell count ( 32888494)	Acne (severe) ( 30542056) Blood protein levels ( 28240269) Body mass index ( 25673413) Body shape index ( 34021172) Irritable bowel syndrome ( 24797007) Mosquito bite size ( 28199695) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		38 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 ASH2L BACE1 CNMD COL23A1 DSG3 EDA FES FGF2 FLNA FLNC IDH2 IL1B ITM2C LRP1 MMP14 NAGPA NOTCH1 NPC1 NUCB2 PACS1 PDE4D PDGFA PELO PMCH PRB4 SERPINB8 SORCS1 SORL1 TMOD3 TNFSF13 VWF ZP3 ZP4	34 interacting genes: API5 BBS9 CASP1 CD44 CEP57 CRYAB CSNK2A1 CSNK2A2 CSNK2B CXCL13 FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FGFRL1 FURIN GPC3 GPC4 HSPG2 IL2 NRP1 PF4 PRMT1 PTX3 RPL6 RPS19 RPS6KA3 SDC1 SDC2 SDC3 SNTG1 THBS1 VTN
Entrez ID		5045	2247
HPRD ID		00653	00622
Ensembl ID		ENSG00000140564	ENSG00000138685
Uniprot IDs		A0A024RC70 P09958	P09038
PDB IDs		4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD 6YD2 6YD3 6YD4 6YD7	1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 2M49 4FGF 4OEE 4OEF 4OEG 5X1O 6L4O
Enriched GO Terms of Interacting Partners?
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