PDC and GRK2

Number of citations of the paper that reports this interaction (PubMedID 10884381)
12

Data Source:
HPRD (in vitro)

		PDC	GRK2
Description		phosducin	G protein-coupled receptor kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Cytosol	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse
	Molecular Function	Phospholipase Inhibitor Activity	G Protein-coupled Receptor Binding Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity	Regulation Of The Force Of Heart Contraction Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Regulation Of Signal Transduction Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle
Pathways			Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis
Drugs			ATP
Diseases
GWAS
Interacting Genes		6 interacting genes: CAMK2A CRX GRK2 PRKACA PSMC5 YWHAZ	51 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2
Entrez ID		5132	156
HPRD ID		01373	00182
Ensembl ID		ENSG00000116703	ENSG00000173020
Uniprot IDs		A0A024R982 P20941 Q52LP8	A0A0S2Z392 P25098
PDB IDs			1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z
Enriched GO Terms of Interacting Partners?
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