GRK2 and RPLP2

Number of citations of the paper that reports this interaction (PubMedID 14729942)
27

Data Source:
HPRD (in vitro, in vivo)

		GRK2	RPLP2
Description		G protein-coupled receptor kinase 2	ribosomal protein lateral stalk subunit P2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse	Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity	Structural Constituent Of Ribosome Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Regulation Of Signal Transduction Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle	Cytoplasmic Translational Elongation Translation
Pathways		Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		ATP
Diseases
GWAS			Intraocular pressure ( 29785010) Keratoconus ( 33649486)
Interacting Genes		51 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2	8 interacting genes: GRK2 LINC00839 MAPK8 PTEN RPLP1 SRPK2 TIMM10B YWHAQ
Entrez ID		156	6181
HPRD ID		00182	01612
Ensembl ID		ENSG00000173020	ENSG00000177600
Uniprot IDs		A0A0S2Z392 P25098	A0A024RCA7 P05387
PDB IDs		1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z	1S4J 2JDL 2LBF 2W1O 4BEH 4V6X 5DDZ 5GU4
Enriched GO Terms of Interacting Partners?
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