INSIG2 and PCK1

Number of citations of the paper that reports this interaction (PubMedID 32322062)
16

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		INSIG2	PCK1
Description		insulin induced gene 2	phosphoenolpyruvate carboxykinase 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Oxysterol Binding	Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding GDP Binding Manganese Ion Binding Carboxylic Acid Binding Protein Serine Kinase Activity (using GTP As Donor)
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid	Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process Aging Response To Activity Peptidyl-serine Phosphorylation Propionate Catabolic Process Response To Lipopolysaccharide Response To Insulin Cellular Response To Insulin Stimulus Response To Lipid Glucose Homeostasis Response To Starvation Positive Regulation Of Memory T Cell Differentiation Glycerol Biosynthetic Process From Pyruvate Regulation Of Lipid Biosynthetic Process Cellular Response To Potassium Ion Starvation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Acidic PH Hepatocyte Differentiation Response To Interleukin-6 Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus Response To Methionine
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 5'-Guanylylmethylenebisphosphonate
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)	Emphysema imaging phenotypes ( 26030696) Estimated glomerular filtration rate ( 31152163 31451708) Hematocrit ( 32888494) Hemoglobin ( 32888494) Prudent dietary pattern ( 28644415) Red blood cell count ( 32888494) Response to fenofibrate (adiponectin levels) ( 23149075) Serum alkaline phosphatase levels ( 31666285) Triglycerides ( 30275531) Type 2 diabetes ( 23300278)
Interacting Genes		47 interacting genes: ABHD4 AQP2 AQP6 ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP FAM209A GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MUC1 NEMP1 PCK1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC16A10 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21	9 interacting genes: AKT1 APP C1R FBXO25 IKBKG INSIG1 INSIG2 RAE1 UBR5
Entrez ID		51141	5105
HPRD ID		16361	02028
Ensembl ID		ENSG00000125629	ENSG00000124253
Uniprot IDs		A0A024RAI2 B4DQ23 Q9Y5U4	P35558
PDB IDs		4J82 6M49	1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV
Enriched GO Terms of Interacting Partners?
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