INSIG2 and SLC16A10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		INSIG2	SLC16A10
Description		insulin induced gene 2	solute carrier family 16 member 10
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Cell Junction Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Oxysterol Binding	Protein Binding Amino Acid Transmembrane Transporter Activity Aromatic Amino Acid Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity
	Biological Process	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Fatty Acid Biosynthetic Process Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid	Amino Acid Transmembrane Transport Thyroid Hormone Generation Amino Acid Transport Aromatic Amino Acid Transport Thyroid Hormone Transport Thyroid-stimulating Hormone Secretion
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)	Amino acid transport across the plasma membrane
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)	Amino acid levels ( 26068415) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood metabolite levels ( 24816252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 23823483 22286219) Metabolite levels (small molecules and protein measures) ( 27005778) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Tyrosine levels ( 31560688) Ulcerative colitis ( 28067908)
Interacting Genes		47 interacting genes: ABHD4 AQP2 AQP6 ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP FAM209A GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MUC1 NEMP1 PCK1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC16A10 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21	4 interacting genes: FUNDC2 INSIG2 RACGAP1 TMEM14B
Entrez ID		51141	117247
HPRD ID		16361	09613
Ensembl ID		ENSG00000125629	ENSG00000112394
Uniprot IDs		A0A024RAI2 B4DQ23 Q9Y5U4	Q8TF71
PDB IDs		4J82 6M49
Enriched GO Terms of Interacting Partners?
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